@article{oai:rakuno.repo.nii.ac.jp:00002137,
 author = {OGIWARA, Katsuro and Iwabu, Yukie and Kanai, Yuta and Miyasho, Taku and Daidoji, Tomo and Yunoki, Mikihiro and Tsujikawa, Muneo and Ohkubo, Yuuji and Yasue, Hiroshi and Ikuta, Kazuyoshi},
 journal = {The Open Veterinary Science Journal},
 month = {Nov},
 note = {Article, HEV infections in human and pigs have been reported in many countries; however, the precise distribution and multiplication of this virus in the host remains poorly understood. In this study, we examined the distribution and multiplication of HEV genotype 3 in two piglets at the early phase of intravenous infection, and also examined the virus distribution in a naturally infected pig. We developed real-time RT-PCR to determine copy numbers of the HEV genome in the sera, feces and organs. HEV-RNA was detected in serum from a pig transiently for 7 days post-inoculation (dpi). The HEV copy numbers in the feces appearing 7 dpi were increased to 3.4x106 copies/g at 14 dpi. In contrast, the higher copy numbers of HEV were widely distributed in the tissue organs from naturally HEV-infected pig. The study showed that intravenously inoculated HEV was distributed in several restricted tissues, such as in the liver and intestine.},
 pages = {1--6},
 title = {Distribution and Propagation of Hepatitis E Virus in Experimentally Infected Swine},
 volume = {1},
 year = {2007}
}