{"created":"2023-06-19T07:00:44.276969+00:00","id":2157,"links":{},"metadata":{"_buckets":{"deposit":"588b1389-87ec-4e84-8c81-5135c30f1dc2"},"_deposit":{"created_by":3,"id":"2157","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2157"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002157","sets":["9:27:28:29"]},"author_link":["5445","5440","5437","5436","5442","5444","5438","5441","5439","5443"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"The Open Veterinary Science Journal"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we evaluated the effectiveness of isoprothiolane in preventing fatty liver in dairy cows. Eight pregnant Holstein cows with high body condition scores were studied. Four cows were administered isoprothiolane via feed at 10 g/day/head from 21 days before delivery (treated group), while the remaining four cows received no treatment (non-treated group). Liver samples from both groups were obtained 21 days before delivery and 2 days following delivery. No accumulation of lipid droplets in hepatocytes was observed in any cows prior to delivery. Following delivery, the accumulation of lipid droplets in hepatocytes was significantly reduced in the treated group compared to the non-treated group. The number of mitochondria per unit area was also significantly smaller in the treated group than in the non-treated group. Blood and biochemical test results from cows in the treated group showed an increase in mGOT levels and stable intrahepatic ATP production. These results suggest that isoprothiolane treatment intensified beta-oxidation in liver mitochondria, thereby activating the TCA cycle and maintaining intrahepatic ATP production.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BENTHAM OPEN"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2174/1874318801307010001","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Minaguchi et al.; Licensee Bentham Open. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use,"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minaguchi, Jun A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Michisaburo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oikawa, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Handa, Fumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haraguchi, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyamoto-Ohno, Kazuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosaka, Yoshinao Z."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Hiromi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takehana, Kazushige"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2014-183_minaguchi.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2014-183_minaguchi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2157/files/S-2014-183_minaguchi.pdf"},"version_id":"2be23135-4538-4264-80c1-110c38d763e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fatty liver","subitem_subject_scheme":"Other"},{"subitem_subject":"isoprothiolane","subitem_subject_scheme":"Other"},{"subitem_subject":"beta-oxidation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effectiveness of Isoprothiolane in Preventing Fatty Liver in Dairy Cows","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effectiveness of Isoprothiolane in Preventing Fatty Liver in Dairy Cows"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-12"},"publish_date":"2015-05-12","publish_status":"0","recid":"2157","relation_version_is_last":true,"title":["Effectiveness of Isoprothiolane in Preventing Fatty Liver in Dairy Cows"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:56:29.755942+00:00"}