{"created":"2023-06-19T07:00:44.404130+00:00","id":2160,"links":{},"metadata":{"_buckets":{"deposit":"237869bb-0b2d-4615-a9f6-5172b50a5a31"},"_deposit":{"created_by":3,"id":"2160","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2160"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002160","sets":["9:27:28:29"]},"author_link":["5464","5460","5468","5463","5466","5465","5462","5461","5467"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"907","bibliographicPageStart":"903","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Molecular Medicine Reports"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was designed to investigate the effects of Bowman-Birk inhibitor concentrate (BBIC) on anti-proliferation, up-regulation of Connexin 43 (Cx43) expression and inhabitation of hepatic metastasis in mice with M5076 ovarian sarcoma. M5076 ovarian sarcomas (1x10^6 cells/animal) were subcutaneously transplanted into the back of BDF_1 mice. The ‘pre-treated’ (n=10) and ‘post-treated’ (n=10) groups were fed a standard diet (CE-2) compounded with 0.5% BBI from 3 weeks before and from the day of tumor inoculation, respectively, until 4 weeks after tumor inoculation. The ‘control group’ (n=10) was fed CE-2 alone. Relative tumor weights in the pre- (0.013±0.010) and post- (0.012±0.013) treated groups were significantly reduced by 30.0 and 32.5%, respectively, as compared to the control group (0.040±0.022, p<0.01). The relative densities of Cx43 mRNA and Cx43 protein were significantly higher in the BBIC-treated groups than in the control group. The median numbers of macroscopic spontaneous metastases were significantly lower in the pre- (1.0±2.3) and post- (1.9±3.6) treated groups than in the control group (71.4±97.3). These results suggest that BBIC reduces proliferation as a result of increased expression of Cx43 genes in mice with M5076 ovarian sarcoma. In addition, BBIC inhibits hepatic metastasis in M5076-bearing mice.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/mmr_00000048","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1791-2997","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakurai, Noritaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sano, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Teruyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Hisashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Yukie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sadzuka, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Ryuji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-553_Suzuki.pdf","filesize":[{"value":"120.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-553_Suzuki.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2160/files/S-553_Suzuki.pdf"},"version_id":"1235363e-5c80-4c3f-85cd-facaab2665b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma bearing mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma bearing mice"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-31"},"publish_date":"2011-03-31","publish_status":"0","recid":"2160","relation_version_is_last":true,"title":["Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma bearing mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:56:26.150027+00:00"}