{"created":"2023-06-19T07:00:44.615696+00:00","id":2165,"links":{},"metadata":{"_buckets":{"deposit":"ef7b9c75-1d8c-4e92-93bc-1ad5ac41bb17"},"_deposit":{"created_by":3,"id":"2165","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2165"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002165","sets":["9:27:28:29"]},"author_link":["5494","5496","5495","5498","5497"],"item_7_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2&3","bibliographicPageEnd":"70","bibliographicPageStart":"63","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Veterinary Research"}]}]},"item_7_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_7_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, the antiviral effects of bovine interferon-τ (boIFN-τ) on bovine viral diarrhea virus (BVDV) were examined in vitro and in vivo. In the in vitro experiments, the replication of cytopathic and non-cytopathic BVDV was inhibited in the bovine cells treated with boIFN-τ. The replication of BVDV was completely suppressed by boIFN-τ at a concentration higher than 10^<2> U/ml. In order to examine the effect of boIFN-τ on virus propagation in cattle persistently infected (PI) with non-cytopathic BVDV, boIFN-τ was subcutaneously administered to PI cattle at 10^<5> U/kg or 10^<6> U/kg body weight 5 times per week for 2 weeks. No physical abnormality such as depression was observed in the cattle during the experiment. The mean BVDV titers in the serum of the PI cattle decreased slightly during the boIFN-τ administration period with the dose of 10^<6> U/kg. However, the BVDV titers in the serum returned to the pre-administration level after the final boIFN-τ administration. These results suggest that boIFN-τ demonstrates an anti-BVDV effect, reducing the BVDV level in serum transiently when injected into PI cattle.","subitem_description_type":"Abstract"}]},"item_7_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Graduate School of Veterinary Medicine, Hokkaido University"}]},"item_7_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0047-1917","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kohara, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishikura, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Konnai, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tajima, Motoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onuma, Misao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2013-128_tajima.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2013-128_tajima.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2165/files/S-2013-128_tajima.pdf"},"version_id":"675ed0d6-574b-4902-8cd6-e3d2beb7d037"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bovine viral diarrhea virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Cattle","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon-τ","subitem_subject_scheme":"Other"},{"subitem_subject":"Persistent infection","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus"}]},"item_type_id":"7","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-16"},"publish_date":"2014-06-16","publish_status":"0","recid":"2165","relation_version_is_last":true,"title":["Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:56:20.087829+00:00"}