@article{oai:rakuno.repo.nii.ac.jp:00002166,
 author = {ISHIZUKA, Tomohito and TAMURA, Jun and NAGARO, Tsukasa and SUDO, Kanako and ITAMI, Takaharu and UMAR, Mohammed Ahamed and 三好, 健二郎 and SANO, Tadashi and YAMASHITA, Kazuto and 山下, 和人},
 issue = {12},
 journal = {The Journal of Veterinary Medical Science},
 month = {Dec},
 note = {Article, Effects of intermittent positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses anesthetized with total intravenous anesthesia using constant rate infusions of medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24 µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses were anesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossover study). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation (SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameters were observed for 120 min. In the SB-group, cardiovascular parameters were maintained within acceptable ranges (heart rate: 33-35 beats/min, cardiac output: 27-30 l/min, mean arterial blood pressure [MABP]: 114-123 mmHg, mean pulmonary arterial pressure [MPAP]: 28-29 mmHg and mean right atrial pressure [MRAP]: 19-21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterial CO_2 pressure [PaCO_2]: 84-103 mmHg and arterial O_2 pressure [PaO_2]: 155-172 mmHg). In the CV-group, normocapnea (PaCO_2: 42-50 mmHg) and good oxygenation (PaO_2: 395-419 mmHg) were achieved by the IPPV without apparent cardiovascular depression (heart rate: 29-31 beats/min, cardiac output: 17-21 l /min, MABP: 111-123 mmHg, MPAP: 27-30 mmHg and MRAP: 15-16 mmHg). MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated.},
 pages = {1577--1582},
 title = {Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)},
 volume = {76},
 year = {2014}
}