{"created":"2023-06-19T07:00:45.496629+00:00","id":2186,"links":{},"metadata":{"_buckets":{"deposit":"c9ad135d-1c45-4eee-a972-3d3f72bd684f"},"_deposit":{"created_by":3,"id":"2186","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2186"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002186","sets":["9:27:28:29"]},"author_link":["5621","5630","5624","5626","5627","5629","5628","5625","5623","5622"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"357","bibliographicPageStart":"343","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Genes to Cells"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The endotheliotropism of equine herpesvirus-1 (EHV-1) leads to encephalomyelitis secondary to vasculitis and thrombosis in the infected horse central nervous system (CNS). To identify the host factors involved in EHV-1 infection of CNS endothelial cells, we performed functional cloning using an equine brain microvascular endothelial cell cDNA library. Exogenous expression of equine major histocompatibility complex (MHC) class I heavy chain genes conferred susceptibility to EHV-1 infection in mouse NIH3T3 cells, which are not naturally susceptible to EHV-1 infection. Equine MHC class I molecules bound to EHV-1 glycoprotein D (gD), and both anti-gD antibodies and a soluble form of gD blocked viral entry into NIH3T3 cells stably expressing the equine MHC class I heavy chain gene (3T3-A68 cells). Treatment with an anti-equine MHC class I monoclonal antibody blocked EHV-1 entry into 3T3-A68 cells, equine dermis (E. Derm) cells and equine brain microvascular endothelial cells. In addition, inhibition of cell surface expression of MHC class I molecules in E. Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Molecular Biology Society of Japan / Blackwell Publishing Ltd"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1365-2443.2011.01491.x","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1356-9597","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Michihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasebe, Rie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makino, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Tadaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushi, Hideto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniyama, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawa, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Takashi"}],"nameIdentifiers":[{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-04"},"publish_date":"2013-06-04","publish_status":"0","recid":"2186","relation_version_is_last":true,"title":["Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:55:54.923787+00:00"}