@article{oai:rakuno.repo.nii.ac.jp:00002189,
 author = {久枝, 啓一 and 有馬, 春樹 and 園部, 隆久 and 那須, 正信 and HAGIWARA, Katsuro and 萩原, 克郎 and 桐沢, 力雄 and 岩井, 浤 and 永幡, 肇},
 issue = {6},
 journal = {日本獣医師会雑誌},
 month = {Jun},
 note = {Article, Escherichia coliによる甚急性乳房炎牛および健康牛の血清中ならびに乳清中サイトカイン（IL-1β，IL-1ra，IL-6，IFN-γおよびTNF-α）濃度を測定し臨床症状との関連性を検討した．乳房炎牛群の初診時の血清中IL-1β，IL-6およびIFN-γ濃度は，健康牛群のそれより高値であった．初診時の乳清中サイトカイン濃度は，いずれも健康牛群のそれよりも高値を示したが，回復に伴い減少傾向が認められた．乳房炎牛群の初診時の血清中および乳清中IL-6濃度，乳清中IFN-γ濃度と臨床症状との間に相関性（それぞれP＜0.05）を認めた．乳房炎牛群の初診時における血清中および乳清中サイトカイン濃度は，全身ならびに乳房の特徴的な病態の発現に関与しているものと示唆される．This study was conducted to determine the concentrations of cytokines, interleukin (IL)-1β, IL-1 receptor antagonist (ra), IL-6, interferon (IFN)- γ and tumor necrosis factor (TNF)-α in serum and whey from clinically healthy cows and cows with peracute coliform mastitis, and to evaluate the association of increased cytokine levels in mastitic cows with their clinical findings. The concentrations of IL-1β, IL-6, and IFN- γ in serum and whey from E. coli mastitic cows at the onset of mastitis were apparently increased, compared with those of healthy cows. Increased levels of cytokine concentrations in whey were reduced during the mastitis recovery process of. Correlations were found between increased levels of IL-6 in serum and whey and IFN- γ in whey and their characteristic findings in E. coli mastitic cows at the day of diagnosis. These findings suggest that increased levels of cytokine concentrations in dairy cows with E. coli mastitis may be associated with the pathogenesis and their characteristic findings.},
 pages = {443--448},
 title = {Escherichia coliによる乳牛の甚急性乳房炎における血清中および乳清中サイトカインの動態と臨床症状},
 volume = {61},
 year = {2008}
}