{"created":"2023-06-19T07:00:48.907064+00:00","id":2267,"links":{},"metadata":{"_buckets":{"deposit":"1b24b602-ac40-4d01-b041-8226f59f670c"},"_deposit":{"created_by":3,"id":"2267","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2267"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002267","sets":["9:27:28:29"]},"author_link":["6124","6126","6127","6135","6130","6125","6132","6129","6131","6134","6133","6128"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7802-14","bibliographicPageStart":"7802-1","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Nature Communications"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lamina propria (LP) macrophages are constantly exposed to commensal bacteria, and are refractory to those antigens in an interleukin (IL)-10-dependent fashion. However, the mechanisms that discriminate hazardous invasion by bacteria from peaceful co-existence with them remain elusive. Here we show that CD169^+ macrophages reside not at the villus tip, but at the bottom-end of the LP microenvironment. Following mucosal injury, the CD169^+ macrophages recruit inflammatory monocytes by secreting CCL8. Selective depletion of CD169^+ macrophages or administration of neutralizing anti-CCL8 antibody ameliorates the symptoms of experimentally induced colitis in mice. Collectively, we identify an LP-resident macrophage subset that links mucosal damage and inflammatory monocyte recruitment. Our results suggest that CD169^+ macrophage-derived CCL8 serves as an emergency alert for the collapse of barrier defence, and is a promising target for the suppression of mucosal injury.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Macmillan Publishers Limited"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/ncomms8802","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asano, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Naomichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ushiki, Mikiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Monya, Misa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aihara, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuboki, Erika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriyama, Shigetaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iida, Mayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Qiu, Chun-Hong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masato"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2016-175_kitamura.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-175_kitamura.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2267/files/S-2016-175_kitamura.pdf"},"version_id":"5e448726-cf57-4895-9c5c-540811010f14"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intestinal CD169^+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intestinal CD169^+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"2267","relation_version_is_last":true,"title":["Intestinal CD169^+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:54:43.301916+00:00"}