{"created":"2023-06-19T07:00:51.067972+00:00","id":2318,"links":{},"metadata":{"_buckets":{"deposit":"5b952f9b-823b-49b3-885d-13bdc909bd20"},"_deposit":{"created_by":3,"id":"2318","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2318"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002318","sets":["9:27:28:29"]},"author_link":["4637","6488","6486","6484","6483","6487","4638","6485"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"886","bibliographicPageStart":"881","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GM1 gangliosidosis is one of the inherited metabolic lysosomal storage disorders characterized by neurological symptoms caused by β-galactosidase deficiency and consequent accumulation of GM1 ganglioside in neuronal cells. Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of neutral carbohydrates, resulting in the loss of normal arrangement of collagen fibrils in the opaque cornea was found to be associated with the disorder. We therefore conclude that corneal opacity in this Shiba dog with GM1 gangliosidosis may be caused by neutral carbohydrate accumulation in lysosomes, swelling and dysfunction of keratocytes, and subsequent irregular arrangement of collagen fibrils in the corneal proper substance.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1292/jvms.70.881","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAGAYASU, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Taito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMATO, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUZUKI, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HOSAKA, Yoshinao"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"UEDA, Hiromi","creatorNameLang":"en"},{"creatorName":"植田, 弘美","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TANGKAWATTANA, Prasarn"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEHANA, Kazushige"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-539_Takehana.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-539_Takehana.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2318/files/S-539_Takehana.pdf"},"version_id":"2939dbfd-c165-4057-abd6-b892715f8117"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-31"},"publish_date":"2011-03-31","publish_status":"0","recid":"2318","relation_version_is_last":true,"title":["Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:54:00.280575+00:00"}