{"created":"2023-06-19T07:00:54.119319+00:00","id":2390,"links":{},"metadata":{"_buckets":{"deposit":"f55fbe52-2150-4cf1-97a8-3ab601451869"},"_deposit":{"created_by":3,"id":"2390","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2390"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002390","sets":["9:27:28:29"]},"author_link":["6977","6981","6978","6979","6980"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"349751-7","bibliographicPageStart":"349751-1","bibliographicVolumeNumber":"2015","bibliographic_titles":[{"bibliographic_title":"Evidence-Based Complementary and Alternative Medicine"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myoblast activation is a triggering event for muscle remodeling. We assessed the stimulatory effects of propolis, a beehive product, on myoblasts. After an 8 h treatment with 100 μg/mL of Brazilian propolis ethanol extract, expression of various chemokines, including CCL-2 and CCL-5, and cytokines, such as IL-6, increased. This propolis-induced cytokine production appears to depend on NF-κB activation, because the IKK inhibitor BMS-345541 repressed mRNA levels of CCL-2 by ~66%, CCL-5 by ~81%, and IL-6 by ~69% after propolis treatment. Supernatant from propolis-conditioned C2C12 cells upregulated RAW264 macrophage migration. The supernatant also stimulated RAW264 cells to produce angiogenic factors, including VEGF-A and MMP-12. Brazilian green propolis therefore causes myoblasts to secrete cytokines and chemokines, which might contribute to tissue remodeling of skeletal muscle.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2015/349751","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015 Kohei Washio et al."},{"subitem_rights":"This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/3.0/ | https://creativecommons.org/licenses/by/3.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Washio, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Mao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Natsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amagasa, Misato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2016-158_kitamura.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-158_kitamura.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2390/files/S-2016-158_kitamura.pdf"},"version_id":"d079e2fe-d63c-4d67-bafe-5e97d17ed330"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"2390","relation_version_is_last":true,"title":["Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:52:35.163431+00:00"}