{"created":"2023-06-19T07:00:54.162075+00:00","id":2391,"links":{},"metadata":{"_buckets":{"deposit":"cee57632-3fda-4eb6-be5f-b377360c6aee"},"_deposit":{"created_by":3,"id":"2391","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2391"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002391","sets":["9:27:28:29"]},"author_link":["5064","4513","6982","6518","6983"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"756","bibliographicPageStart":"751","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We performed proteomics analysis of the cerebrospinal fluid (CSF) of healthy dogs and dogs with meningoencephalitis of unknown etiology (MUE). By comparing two-dimensional electrophoreses (2DE), an upregulated spot was found in MUE dogs. This protein was identified as a neuron-specific enolase (NSE) by analysis with MALDI-TOF mass spectrometry. In comparing dot blots using an antibody against NSE, the NSE levels in the CSF of MUE dogs was significantly higher than that of the controls. NSE is a diagnostic marker of neuroendocrine tumors, brain injury and spinal cord trauma in humans. It seems that the NSE concentration in the CSF is increased by cellular destruction in canine encephalitis. Though elevation of NSE may not be specific in canine encephalitis because the NSE level was increased in other CNS diseases, further study including measurement with serum is necessary.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1292/jvms.11-0474","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAMURA, Kozo"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"MIYASHO, Taku","creatorNameLang":"en"},{"creatorName":"宮庄, 拓","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NOMURA, Sachiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOTA, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKADE, Tetsuya"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2013-121_nakade.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2013-121_nakade.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2391/files/S-2013-121_nakade.pdf"},"version_id":"8b4ffeb1-69a7-43ac-b52d-f0649d8c1954"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2DE","subitem_subject_scheme":"Other"},{"subitem_subject":"canine","subitem_subject_scheme":"Other"},{"subitem_subject":"CSF","subitem_subject_scheme":"Other"},{"subitem_subject":"encephalitis","subitem_subject_scheme":"Other"},{"subitem_subject":"proteome","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-16"},"publish_date":"2014-06-16","publish_status":"0","recid":"2391","relation_version_is_last":true,"title":["Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:18:05.724006+00:00"}