@article{oai:rakuno.repo.nii.ac.jp:00002438, author = {SAEKI, Kohei and ENDO, Yoshifumi and UCHIDA, Kazuyuki and NISHIMURA, Ryohei and SASAKI, Nobuo and NAKAGAWA, Takayuki}, issue = {2}, journal = {Journal of Veterinary Medical Science}, month = {Feb}, note = {Article, The numbers of tumor infiltrating T lymphocytes, B lymphocytes and antigen presenting cells were evaluated in an immunohistochemical manner in 140 canine spontaneous mammary gland tumor (MGT) tissues. As a result, we found a statistically significant increase in the number of intratumoral T lymphocytes (23.2 ± 23.8) in the malignant MGT group (n=51) compared with the benign MGT group (14.0 ± 16.0, n=89; P<0.05). Moreover, the high T lymphocyte infiltration in the malignant group correlated with poor prognosis in multivariate analysis (P<0.05). This study indicated the relationship between increased infiltrating T lymphocytes and canine MGT malignancy.}, pages = {227--230}, title = {Significance of Tumor-Infiltrating Immune Cells in Spontaneous Canine Mammary Gland Tumor : 140 Cases}, volume = {74}, year = {2012} }