@article{oai:rakuno.repo.nii.ac.jp:00002443,
 author = {TAMURA, Jun and ITAMI, Takaharu and ISHIZUKA, Tomohito and FUKUI, Sho and OOYAMA, Norihiko and 三好, 健二郎 and SANO, Tadashi and YAMASHITA, Kazuto and 山下, 和人},
 issue = {1},
 journal = {The Journal of Veterinary Medical Science},
 month = {Jan},
 note = {Article, Robenacoxib is a newer nonsteroidal anti-inflammatory drug approved for dogs and cats. This study was designed to evaluate the effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Sevoflurane MAC-BAR was determined by judging dogs’ response to a noxious electrical stimulus (50 V, 50 Hz and 10 msec) for 10 sec in 6 beagle dogs on two occasions at least a 7-day interval. In each occasion, saline (0.1 ml/kg) or robenacoxib (2 mg/kg) was administered subcutaneously at 1 hr prior to the MAC-BAR determination. Robenacoxib significantly decreased the sevoflurane MAC-BAR (3.44 ± 0.53% for saline vs. 2.84 ± 0.38% for robenacoxib, P=0.039). These results suggest that subcutaneous robenacoxib provides a clinically relevant sparing effect on anesthetic requirement.},
 pages = {113--117},
 title = {Sparing Effect of Robenacoxib on the Minimum Alveolar Concentration for Blunting Adrenergic Response (MAC-BAR) of Sevoflurane in Dogs},
 volume = {76},
 year = {2014}
}