{"created":"2023-06-19T07:00:56.524084+00:00","id":2447,"links":{},"metadata":{"_buckets":{"deposit":"f3f80fef-1d2f-445a-a6ab-2a73e813330c"},"_deposit":{"created_by":3,"id":"2447","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2447"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002447","sets":["9:27:28:29"]},"author_link":["7355"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"46","bibliographicPageStart":"43","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Current Trends in Immunology"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human T-cell leukemia virus type 1 (HTLV-1) can cause adult T-cell leukemia/lymphoma (ATLL) and inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). My research group established a transgenic (Tg) mouse model of HTLV-1 infection using the distal promoter of Lck to induce tax expression in mature thymocytes and peripheral T lymphocytes. The major disease phenotypes in this model were mature T cell leukemia/lymphoma, similar to ATLL, and inflammatory arthropathy. While expanding Tax-Tg mouse colony, my group found that about 2% of the Tg mice developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)-like disease. SJS/TEN-like lesions were characterized by a rash and diffuse exfoliation of large areas of the skin, similar to second-degree burns. The pathology of Tg mice with SJS/TEN-like disease included epidermal necrosis and detachment at the dermoepidermal junction. Serum soluble Fas ligand levels were significantly increased in Tax-Tg mice with SJS/TEN-like disease.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Trends"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohsugi, Takeo"}],"nameIdentifiers":[{"nameIdentifier":"7355","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2015-170_osugi.pdf","filesize":[{"value":"103.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2015-170_osugi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2447/files/S-2015-170_osugi.pdf"},"version_id":"02a12a82-6ab6-455d-a321-c09925cd3646"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SJS-TEN","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"ATLL","subitem_subject_scheme":"Other"},{"subitem_subject":"Tax","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mice","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-23"},"publish_date":"2016-05-23","publish_status":"0","recid":"2447","relation_version_is_last":true,"title":["Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:51:30.714916+00:00"}