{"created":"2023-06-19T07:00:57.370591+00:00","id":2467,"links":{},"metadata":{"_buckets":{"deposit":"d51329d0-7bec-4ba6-8a9e-659a07936fb0"},"_deposit":{"created_by":3,"id":"2467","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2467"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002467","sets":["9:27:28:29"]},"author_link":["7468","7464","7465","4519","4715","7467","7469","7466","4914"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"296","bibliographicPageStart":"289","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"The Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) administration to 6 healthy beagle dogs. The dogs received three IM doses each of alfaxalone at increasing dose rates of 5 mg/kg (IM5), 7.5 mg/kg (IM7.5) and 10 mg/kg (IM10) every other day. Anesthetic effect was subjectively evaluated by using an ordinal scoring system to determine the degree of neuro-depression and the quality of anesthetic induction and recovery from anesthesia. Cardiorespiratory variables were measured using noninvasive methods. Alfaxalone administered IM produced dose-dependent neuro-depression and lateral recumbency (i.e., 36 ± 28 min, 87 ± 26 min and 115 ± 29 min after the IM5, IM7.5 and IM10 treatments, respectively). The endotracheal tube was tolerated in all dogs for 46 ± 20 and 58 ± 21 min after the IM7.5 and IM10 treatments, respectively. It was not possible to place endotracheal tubes in 5 of the 6 dogs after the IM5 treatment. Most cardiorespiratory variables remained within clinically acceptable ranges, but hypoxemia was observed by pulse oximetry for 5 to 10 min in 2 dogs receiving the IM10 treatment. Dose-dependent decreases in rectal temperature, respiratory rate and arterial blood pressure also occurred. The quality of recovery was considered satisfactory in all dogs receiving each treatment; all the dog exhibited transient muscular tremors and staggering gait. In conclusion, IM alfaxalone produced a dose-dependent anesthetic effect with relatively mild cardiorespiratory depression in dogs. However, hypoxemia may occur at higher IM doses of alfaxalone.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1292/jvms.14-0368","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAMURA, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIZUKA, Tomohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKUI, Sho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OYAMA, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWASE, Kodai"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"三好, 健二郎","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SANO, Tadashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"PASLOSKE, Kirby"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"YAMASHITA, Kazuto","creatorNameLang":"en"},{"creatorName":"山下, 和人","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2016-187_yamashita.pdf","filesize":[{"value":"554.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-187_yamashita.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2467/files/S-2016-187_yamashita.pdf"},"version_id":"a1ebd525-0c29-4070-9340-83a00e3192e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alfaxalone","subitem_subject_scheme":"Other"},{"subitem_subject":"anesthetic effect","subitem_subject_scheme":"Other"},{"subitem_subject":"canine","subitem_subject_scheme":"Other"},{"subitem_subject":"intramuscular","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"2467","relation_version_is_last":true,"title":["The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:10:52.698584+00:00"}