{"created":"2023-06-19T07:00:58.342706+00:00","id":2490,"links":{},"metadata":{"_buckets":{"deposit":"74655140-1c40-48a3-b8ee-7cb131f3dc01"},"_deposit":{"created_by":3,"id":"2490","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2490"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002490","sets":["9:27:28:29"]},"author_link":["7579","5064","7575","7576","7578","7580","4493","7577"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1484","bibliographicPageStart":"1479","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"The Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this effective metabolizing system is weak in the fetus. In the present study, we demonstrated that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the fetus and newborn pups, and was increased to the same level as BPA post-partum. In conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism during the perinatal period, suggesting that the metabolism of individual Bisphenol analogs requires assessment to properly gauge their risks.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1292/jvms.15-0197","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YABUSAKI, Risa"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"岩野, 英知","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TSUSHIMA, Sumito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOIKE, Nanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHTANI, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANEMURA, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOTA, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2016-205_yokota.pdf","filesize":[{"value":"679.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-205_yokota.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2490/files/S-2016-205_yokota.pdf"},"version_id":"bcfe36cc-15d2-4576-a949-dfe000e5dfd1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bisphenol A","subitem_subject_scheme":"Other"},{"subitem_subject":"Bisphenol AF","subitem_subject_scheme":"Other"},{"subitem_subject":"Bisphenol F","subitem_subject_scheme":"Other"},{"subitem_subject":"UDP glucuronosyl transferase (UGT)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"2490","relation_version_is_last":true,"title":["Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:23:29.606706+00:00"}