{"created":"2023-06-19T07:01:46.978717+00:00","id":3643,"links":{},"metadata":{"_buckets":{"deposit":"e1ad506b-767c-450a-8b21-25085c58a21e"},"_deposit":{"created_by":3,"id":"3643","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3643"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00003643","sets":["9:27:33:34"]},"author_link":["9393","9386","9382","9390","9392","9385","9391","9388","9389","9384","9381","9387","9383","9380"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"e0003914-15","bibliographicPageStart":"e0003914-1","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLoS Neglected Tropical Diseases"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Canine distemper virus (CDV) vaccination confers long-term protection against CDV reinfection. To investigate the utility of CDV as a polyvalent vaccine vector for Leishmania, we generated recombinant CDVs, based on an avirulent Yanaka strain, that expressed Leishmania antigens: LACK, TSA, or LmSTI1 (rCDV–LACK, rCDV–TSA, and rCDV–LmSTI1, respectively). Dogs immunized with rCDV-LACK were protected against challenge with lethal doses of virulent CDV, in the same way as the parental Yanaka strain. To evaluate the protective effects of the recombinant CDVs against cutaneous leishmaniasis in dogs, dogs were immunized with one recombinant CDV or a cocktail of three recombinant CDVs, before intradermal challenge (in the ears) with infective-stage promastigotes of Leishmania major. Unvaccinated dogs showed increased nodules with ulcer formation after 3 weeks, whereas dogs immunized with rCDV–LACK showed markedly smaller nodules without ulceration. Although the rCDV–TSA- and rCDV–LmSTI1-immunized dogs showed little protection against L. major, the cocktail of three recombinant CDVs more effectively suppressed the progression of nodule formation than immunization with rCDV–LACK alone. These results indicate that recombinant CDV is suitable for use as a polyvalent live attenuated vaccine for protection against both CDV and L. major infections in dogs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pntd.0003914","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2015 Miura et al."},{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miura, Ryuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kooriyama, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoneda, Misako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doki, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sanjoba, Chizu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujiyuki, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugai, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukiyama-Kohara, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshitsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kai, Chieko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-19"}],"displaytype":"detail","filename":"S-2016-177_kooriyama.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-177_kooriyama.pdf","url":"https://rakuno.repo.nii.ac.jp/record/3643/files/S-2016-177_kooriyama.pdf"},"version_id":"700fbd10-b2f6-479c-9389-f1ea236f6f90"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs"}]},"item_type_id":"2","owner":"3","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"3643","relation_version_is_last":true,"title":["Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:35:01.897454+00:00"}