{"created":"2023-06-19T07:01:48.582635+00:00","id":3681,"links":{},"metadata":{"_buckets":{"deposit":"6d608207-50e5-4c79-9e58-202c9fd2377a"},"_deposit":{"created_by":3,"id":"3681","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3681"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00003681","sets":["9:27:33:34"]},"author_link":["9720","9723","9722","9719","9718","9721","9717"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"332","bibliographicPageStart":"329","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"Life Sciences"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【Aims】 Many studies of human subjects have demonstrated the utility of assessing serum levels of endothelin-1 (ET-1) and big ET-1 as clinical biomarkers in cardiopulmonary and neoplastic diseases. In this study we explored the feasibility of using serum big ET-1 as a reliable veterinary marker in dogs with various cardiopulmonary and neoplastic diseases. 【Main methods】 Serum big ET-1 levels were measured by ELISA in dogs with cardiopulmonary (n = 21) and neoplastic diseases (n = 57). Dogs exhibiting cardiopulmonary disease were divided into two groups based on the velocity of tricuspid valve regurgitation (3.0 > m/s) measured by ultrasound: without and with pulmonary hypertension. Big ET-1 levels for the dogs with the diseases were compared with levels in normal healthy dogs (n = 17). 【Key findings】 Dogs with cardiopulmonary disease (4.6 ± 4.6 pmol/l) showed a significantly (P < 0.01) higher level of big ET-1 than healthy control dogs (1.1 ± 0.53 pmol/l). Serum levels in the dogs with pulmonary hypertension (6.2 ± 5.3 pmol/l) were significantly (P < 0.01) higher than those without pulmonary hypertension (2.0 ± 0.6 pmol/l). Dogs with hemangiosarcoma (5.6 ± 2.2 pmol/l), adenocarcinoma (2.0 ± 1.8 pmol/l), histiocytic sarcoma (3.3 ± 1.9 pmol/l), chondrosarcoma or osteosarcoma (3.0 ± 1.6 pmol/l) and hepatocellular carcinoma (2.7 ± 1.8 pmol/l) showed significantly (P < 0.05) higher levels than healthy control dogs. 【Significance】These findings point to the potential of serum big ET-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.lfs.2014.01.002","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license"}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by-nc-nd/3.0/ | http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukumoto, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"9717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanazono, Kiwamu"}],"nameIdentifiers":[{"nameIdentifier":"9718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyasho, Taku"}],"nameIdentifiers":[{"nameIdentifier":"9719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Yoshifumi"}],"nameIdentifiers":[{"nameIdentifier":"9720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kadosawa, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"9721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwano, Hidetomo"}],"nameIdentifiers":[{"nameIdentifier":"9722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchide, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"9723","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-19"}],"displaytype":"detail","filename":"S-2015-210_miyasho.pdf","filesize":[{"value":"279.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2015-210_miyasho.pdf","url":"https://rakuno.repo.nii.ac.jp/record/3681/files/S-2015-210_miyasho.pdf"},"version_id":"f660d5c6-785e-46f4-be9e-49f4d7798f30"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Big endothelin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Dog","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonary hypertension","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs"}]},"item_type_id":"2","owner":"3","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-23"},"publish_date":"2016-05-23","publish_status":"0","recid":"3681","relation_version_is_last":true,"title":["Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:34:26.310595+00:00"}