{"created":"2023-06-19T07:02:56.265014+00:00","id":5147,"links":{},"metadata":{"_buckets":{"deposit":"3d5e3703-a9f4-43c4-8e78-bc78b1bcadca"},"_deposit":{"created_by":3,"id":"5147","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5147"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005147","sets":["9:27:28:29"]},"author_link":["15959","15960","15958","15957"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"656","bibliographicPageStart":"649","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"The Journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.15-0625","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ADACHI, Mami"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HOSHINO, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IZUMI, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAGI, Satoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-12"}],"displaytype":"detail","filename":"R-2017-35_Adachi.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2017-35_Adachi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5147/files/R-2017-35_Adachi.pdf"},"version_id":"648400e5-8df5-4f89-b42c-bffb4de7f429"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"canine hemangiosarcoma dog","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"MAPK pathway","subitem_subject_scheme":"Other"},{"subitem_subject":"PI3K/Akt/m-TOR pathway","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor tyrosine kinase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-12"},"publish_date":"2018-04-12","publish_status":"0","recid":"5147","relation_version_is_last":true,"title":["Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:07:25.646293+00:00"}