{"created":"2023-06-19T07:02:57.994937+00:00","id":5174,"links":{},"metadata":{"_buckets":{"deposit":"b2411dbe-307a-4508-8ad2-05509ea888b4"},"_deposit":{"created_by":3,"id":"5174","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5174"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005174","sets":["9:27:28:29"]},"author_link":["16081","16082","16080","4493","16079","16078"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"737","bibliographicPageStart":"733","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"The Journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In isolated hepatocytes, the environmental estrogen bisphenol A (BPA) is metabolized into a mono-glucuronide and a glucuronide/sulfate diconjugate. Little is known about the fate of the diconjugate in the liver. The present study focused on the metabolism and dispostion of BPA diconjugate in the liver using a perfusion method. In Sprague-Dawley rats, BPA (15,150 or 1,500 nmol) was applied into the liver. In male rats, the infused BPA was conjugated to both glucuronide and a diconjugate during passage through the liver. The diconjugate was observed at high-dose application of the substrate. In female rats, the chemical was conjugated almost exclusively to the glucuronide in all doses utilized in this study. In both the male and female rats, the resultant metabolites were preferentially excreted into the bile. These results suggest that BPA is conjugated primarily to mono-glucuronide in rat liver; and that in males, diconjugate production occurs under conditions of high-dose exposure to BPA.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.15-0573","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"INOUE, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"16078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KEMANAI, Shino"}],"nameIdentifiers":[{"nameIdentifier":"16079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SANO, Chie"}],"nameIdentifiers":[{"nameIdentifier":"16080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KATO, Seiyu"}],"nameIdentifiers":[{"nameIdentifier":"16081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YOKOTA, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"16082","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"岩野, 英知","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{"nameIdentifier":"4493","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9417","nameIdentifierScheme":"教員総覧","nameIdentifierURI":"https://www.rakuno.ac.jp/archives/teacher/9417.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-12"}],"displaytype":"detail","filename":"R-2017-107_Iwano.pdf","filesize":[{"value":"887.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2017-107_Iwano.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5174/files/R-2017-107_Iwano.pdf"},"version_id":"102f8068-6bdd-48bc-9be2-a009fc0ee930"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bisphenol A","subitem_subject_scheme":"Other"},{"subitem_subject":"diconjugation","subitem_subject_scheme":"Other"},{"subitem_subject":"glucuronide conjugation","subitem_subject_scheme":"Other"},{"subitem_subject":"liver perfusion","subitem_subject_scheme":"Other"},{"subitem_subject":"sulfate conjugation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-12"},"publish_date":"2018-04-12","publish_status":"0","recid":"5174","relation_version_is_last":true,"title":["Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:23:27.478619+00:00"}