{"created":"2023-06-19T07:02:58.910125+00:00","id":5188,"links":{},"metadata":{"_buckets":{"deposit":"35e0136f-732d-4d0f-ada2-0e2394a3c2c8"},"_deposit":{"created_by":3,"id":"5188","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5188"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005188","sets":["9:27:28:29"]},"author_link":["16155","16154","4519","4715","16156","16153","16158","16157"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1034","bibliographicPageStart":"1031","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"The Journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aimed to compare the pharmacokinetics of tramadol between young and middle-aged dogs. Tramadol (4 mg/kg) was administered intravenously (IV) to young and middle-aged dogs (2 and 8–10 years, respectively). Plasma concentrations of tramadol were measured using high-performance liquid chromatography (HPLC), and its pharmacokinetics best fit a two-compartment model. The volume of distribution (V_d), elimination half-life (t_<1/2,β>) and total body clearance (CL_<tot>) of the young group were 4.77 ± 1.07 l/kg, 1.91 ± 0.26 hr and 29.9 ± 7.3 ml/min/kg, respectively, while those of the middle-aged group were 4.73 ± 1.43 l/kg, 2.39 ± 0.97 hr and 23.7 ± 5.4 ml/min/kg, respectively. Intergroup differences in the t_<1/2,β> and CL_<tot> were significant (P<0.05). In conclusion, tramadol excretion was significantly prolonged in middle-aged dogs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.15-0638","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ITAMI, Takaharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAITO, Yasuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIZUKA, Tomohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAMURA, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UMAR, Mohammed A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Hiroki"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"三好, 健二郎","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"YAMASHITA, Kazuto","creatorNameLang":"en"},{"creatorName":"山下, 和人","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-12"}],"displaytype":"detail","filename":"R-2017-159_Yamashita.pdf","filesize":[{"value":"434.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2017-159_Yamashita.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5188/files/R-2017-159_Yamashita.pdf"},"version_id":"c07c4dec-7b0d-4073-a923-9083f89aa877"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dog","subitem_subject_scheme":"Other"},{"subitem_subject":"intravenous","subitem_subject_scheme":"Other"},{"subitem_subject":"middle-age","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"tramadol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of pharmacokinetics of tramadol between young and middle-aged dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of pharmacokinetics of tramadol between young and middle-aged dogs"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-12"},"publish_date":"2018-04-12","publish_status":"0","recid":"5188","relation_version_is_last":true,"title":["Comparison of pharmacokinetics of tramadol between young and middle-aged dogs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:10:49.082147+00:00"}