{"created":"2023-06-19T07:02:59.295631+00:00","id":5194,"links":{},"metadata":{"_buckets":{"deposit":"e9c67eb9-33ff-49cd-9271-93af3d0deefb"},"_deposit":{"created_by":3,"id":"5194","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5194"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005194","sets":["9:27:28:29"]},"author_link":["16185","16186","16181","4653","4519","16182","16183","16184"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"95","bibliographicPageStart":"91","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"The Journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A male Japanese domestic cat with retarded growth in Hokkaido, Japan, showed progressive motor dysfunction, such as ataxia starting at 3 months of age and tremors, visual disorder and seizure after 4 months of age. Finally, the cat died of neurological deterioration at 9 months of age. Approximately half of the peripheral blood lymphocytes had multiple abnormal vacuoles. Magnetic resonance imaging showed bisymmetrical hyperintensity in the white matter of the parietal and occipital lobes in the forebrain on T2-weighted and fluid-attenuated inversion recovery images, and mild encephalatrophy of the olfactory bulbs and temporal lobes. The activity of lysosomal acid β-galactosidase in leukocytes was negligible, resulting in the biochemical diagnosis of GM1 gangliosidosis. Histologically, swollen neurons characterized by accumulation of pale, slightly granular cytoplasmic materials were observed throughout the central nervous system. Dysmyelination or demyelination and gemistocytic astrocytosis were observed in the white matter. Ultrastructually, membranous cytoplasmic bodies were detected in the lysosomes of neurons. However, genetic analysis did not identify the c.1448G>C mutation, which is the single known mutation of feline GM1 gangliosidosis, suggesting that the cat was affected with a new variant of the feline disease.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.15-0281","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"UENO, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMATO, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIURA, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOHYAMA, Moeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YABUKI, Akira"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"三好, 健二郎","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"MATSUDA, Kazuya","creatorNameLang":"en"},{"creatorName":"松田, 一哉","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"UCHIDE, Tsuyoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-12"}],"displaytype":"detail","filename":"R-2017-181_Matsuda.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2017-181_Matsuda.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5194/files/R-2017-181_Matsuda.pdf"},"version_id":"e49ebeac-c78b-4afd-bb7a-fe21acdab65b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"β-galactosidase deficiency","subitem_subject_scheme":"Other"},{"subitem_subject":"feline GM1 gangliosidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese domestic cat","subitem_subject_scheme":"Other"},{"subitem_subject":"lysosomal storage disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GM1 gangliosidosis in a Japanese domestic cat: a new variant identified in Hokkaido, Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GM1 gangliosidosis in a Japanese domestic cat: a new variant identified in Hokkaido, Japan"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-12"},"publish_date":"2018-04-12","publish_status":"0","recid":"5194","relation_version_is_last":true,"title":["GM1 gangliosidosis in a Japanese domestic cat: a new variant identified in Hokkaido, Japan"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:10:48.032967+00:00"}