{"created":"2023-06-19T07:02:59.743412+00:00","id":5201,"links":{},"metadata":{"_buckets":{"deposit":"0fb942f7-faea-492c-ad83-b72b26d4975e"},"_deposit":{"created_by":3,"id":"5201","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5201"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005201","sets":["9:27:28:29"]},"author_link":["16227","16225","16226","3576"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"253-4","bibliographicPageStart":"253-1","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"BMC veterinary research"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Borna disease virus is a neurotropic pathogen and infects the central nervous system. This virus infected a variety of animal species including cows. The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical infection without any neurological symptoms throughout their lifetime. We previously reported on the low conception rates in-seropositive cows. Interferon-τ (IFN-τ) plays an important role in stable fertilization, and is produced from the fetal side following embryo growth at 15–40 days of pregnancy. IFN-τ induces the expression of interferon-stimulated gene (ISG) 15 and Mx2 in peripheral blood mononuclear cells (PBMCs). To understand the embryo growth and maternal reaction during early pregnancy in cows with BoDV-1 infection, we aimed to assess the gene expression of ISG15 and Mx2 from PBMCs in BoDV-1-seropositive cows. [Results] None of the cows showed any clinical and neurological symptoms. Among the cows that conceived, the expressions of the ISG15 and Mx2 genes were greater in the BoDV-1-seropositive cows than in the BoDV-1-seronegative cows; the difference was significant between the cows that conceived and those that did not (P < 0.05). [Conclusions] The expression of ISG15 and Mx2 genes during early pregnancy significantly increased in the BoDV-1-seropositive cows and may be important for the maintenance of stable pregnancy in BoDV-1-infected cows. In contrast, the gene expression levels of ISG15 and Mx2 did not significantly increase during early pregnancy in BoDV-1-seronegative cows. Thus, BoDV-1 infection may lead to instability in the maintenance of early pregnancy by interfering with INF-τ production.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"1746-6148","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1186/s12917-016-0883-5","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s). 2016"}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takino, Tadashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamura, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"HAGIWARA, Katsuro","creatorNameLang":"en"},{"creatorName":"萩原, 克郎","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-12"}],"displaytype":"detail","filename":"R-2017-203_Hagiwara.pdf","filesize":[{"value":"385.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2017-203_Hagiwara.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5201/files/R-2017-203_Hagiwara.pdf"},"version_id":"5ab160cb-a799-4ed9-a230-67cc39b7b698"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Interferon-stimulated gene","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-τ","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnant","subitem_subject_scheme":"Other"},{"subitem_subject":"Borna disease virus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-12"},"publish_date":"2018-04-12","publish_status":"0","recid":"5201","relation_version_is_last":true,"title":["Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:45:57.364699+00:00"}