@article{oai:rakuno.repo.nii.ac.jp:00005686,
 author = {加藤, 葉月 and 安岡, 竜太 and OIKAWA, Shin and 及川, 伸 and NAKADA, Ken and 中田, 健},
 issue = {1},
 journal = {産業動物臨床医学雑誌},
 month = {Jun},
 note = {Article, 泌乳初期の潜在性ケトーシス（SCK）牛に対して塩酸ベタインと含糖ペプシンを含む塩酸ベタイン製剤（ ビオペア：BPA，東亜薬品工業，東京）を一定期間経口投与して，その効果を一般に汎用されているプロピレングリコール（PG）と比較検討した．本試験は北海道江別市の１酪農場で実施した．対象牛は2014年11月〜2015年５月までに分娩した54頭である．分娩後３日目および８日目に採血を行い，β-ヒドロキシ酪酸（BHBA）濃度が1.0 mM以上の牛をSCK群とし，無作為に選定されたいずれかの薬剤を採血日からそれぞれ５日間連続で経口投与した．牛によってSCK以外の疾病の発症や薬剤投与期間に違いがあったため，最終的に３日目から10日間連続して試験薬剤のみが投与された13頭が投与群（PG群：７頭，250 mℓ/日，BPA群：６頭，90 g/日）として選定された．また，試験期間を通してBHBA濃度が1.0 mM未満で臨床的に健康な10頭を対照群とした．なお，血液検査は13日目も実施された．一般的血液プロファイルとして，脂質，ミネラル，肝酵素，血糖値を評価した．なお，乳生産や繁殖成績についても調査した．PGおよびBPA群のBHBA濃度は，13日目においても対照群より有意な高値（p<0.01）を示したが，PG群とBPA群の間に差はみられなかった．一方，PGおよびBPA群の非エステル型脂肪酸濃度は，対照群と同程度であった．血糖値は８日目以降投与群と対照群との間に有意差はなかった．初回人工授精までの日数は３群間に明らかな差はなかった．乳生産量ではBPA群が対照群よりも高い傾向（p=0.12）がみられた．なお，泌乳初期のBPA群の乳蛋白率は対照群のそれよりも低かったが異常値ではなかった．以上よりBPAのSCK牛に対する投与はPG投与に劣らず有効であることが示唆された．, Biopair（BPA, Toa Pharmaceutical Co., Ltd., Tokyo, Japan）, a drug product containing betaine hydrochloride and pepsin and indicated for digestive dysfunction, was orally administered to cows in early lactation with subclinical ketosis（SCK）to investigate its efficacy in comparison with propylene glycol（PG）, a commonly used compound with wide-ranging applications. The study was conducted on a dairy farm in Ebetsu, Hokkaido, Japan, and included 54 cows that calved between November 2014 and May 2015. Blood samples were collected at 3, 8 and 13 days postpartum. Cows with a blood β-hydroxybutyrate（BHBA）concentration of 1.0 mM or higher were diagnosed as having SCK and randomly assigned to a treatment with either BPA or PG by oral dosing for 5 consecutive days from the sampling day. Due to individual variability in the onset of clinical disease and duration of dosing, 13 cows receiving consecutive treatment for 10 days from 3 days postpartum were included in the analysis（250 mℓ/day of PG in 7 cows and 90 g/day of BPA in 6 cows）. Additionally, 10 clinically healthy cows having BHBA concentrations below 1.0 mM throughout the study period were used as controls. In addition to BHBA, blood lipids, minerals, liver enzymes and glucose were also assessed. Milk production and reproductive performance were also determined. At 13 days postpartum, the BHBA concentration was significantly higher in the PG and BPA groups than in the control group （p<0.01）but was not significantly different between the PG and BPA groups. The concentrations of nonesterified fatty acids in the PG and BPA groups were similar to those of the control group. The blood glucose level did not significantly differ between the treatment groups and control group from 8 days postpartum. Milk yield, milk composition and reproductive performance did not clearly differ among the three groups, although 4% fat-corrected milk yield was slightly higher in the BPA group than in the control group（p=0.12）. These results suggest that the efficacy of BPA for SCK is similar to that of PG.},
 pages = {7--14},
 title = {泌乳初期の潜在性ケトーシス牛に対する塩酸ベタイン製剤の投与効果},
 volume = {8},
 year = {2017}
}