{"created":"2023-06-19T07:03:25.222145+00:00","id":5715,"links":{},"metadata":{"_buckets":{"deposit":"16af0467-fc97-4272-9337-068db92d81fc"},"_deposit":{"created_by":3,"id":"5715","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5715"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00005715","sets":["9:27:28:29"]},"author_link":["18172","18169","6391","18174","18173","18170","18171"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"172","bibliographicPageStart":"164","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"The Journal of veterinary medical science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyloid A (AA) amyloidosis, a fatal systemic amyloid disease, occurs secondary to chronic inflammatory conditions in humans. Although persistently elevated serum amyloid A (SAA) levels are required for its pathogenesis, not all individuals with chronic inflammation necessarily develop AA amyloidosis. Furthermore, many diseases in cats are associated with the elevated production of SAA, whereas only a small number actually develop AA amyloidosis. We hypothesized that a genetic mutation in the SAA gene may strongly contribute to the pathogenesis of feline AA amyloidosis. In the present study, genomic DNA from four Japanese domestic cats (JDCs) with AA amyloidosis and from five without amyloidosis was analyzed using polymerase chain reaction (PCR) amplification and direct sequencing. We identified the novel variation combination of 45R-51A in the deduced amino acid sequences of four JDCs with amyloidosis and five without. However, there was no relationship between amino acid variations and the distribution of AA amyloid deposits, indicating that differences in SAA sequences do not contribute to the pathogenesis of AA amyloidosis. Immunohistochemical analysis using antisera against the three different parts of the feline SAA protein—i.e., the N-terminal, central, and C-terminal regions—revealed that feline AA contained the C-terminus, unlike human AA. These results indicate that the cleavage and degradation of the C-terminus are not essential for amyloid fibril formation in JDCs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.17-0447","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by-nc-nd/4.0/ | https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TEI, Meina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIDA, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"CHAMBERS, James K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Ken-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAMAMOTO, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OHNO, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"R-2018-307_tamamoto.pdf","filesize":[{"value":"5.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2018-307_tamamoto.pdf","url":"https://rakuno.repo.nii.ac.jp/record/5715/files/R-2018-307_tamamoto.pdf"},"version_id":"41421435-e61e-4c72-9448-deba54faeff1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AA amyloidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"fibril formation","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese domestic cat","subitem_subject_scheme":"Other"},{"subitem_subject":"SAA gene","subitem_subject_scheme":"Other"},{"subitem_subject":"AA amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibril formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese domestic cat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SAA gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-08"},"publish_date":"2019-08-08","publish_status":"0","recid":"5715","relation_version_is_last":true,"title":["Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T07:52:58.345502+00:00"}