{"created":"2023-06-19T07:03:40.054657+00:00","id":6064,"links":{},"metadata":{"_buckets":{"deposit":"6beec31e-c9a2-4c13-9936-33ef22b0b830"},"_deposit":{"created_by":3,"id":"6064","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6064"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006064","sets":["9:27:28:29"]},"author_link":["19363","19364","19361","19360","19359","19356","19357","19358","19355","19362"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"273","bibliographicPageStart":"269","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Blood purification"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Polymyxin B-immobilized fiber (PMX-F) columns are used as therapeutic interventions for septic shock. The clinical efficacy has been reported for 2-h applications, but their ability to adsorb endotoxin over longer treatments has not been fully elucidated. We hypothesized that PMX-F columns are capable of endotoxin removal for more than 2 h. Method: We designed closed circuits incorporating either a PMX-F column with an 8.5-mL priming volume (PMX-01R) or a sham-control column, and used inactivated fetal bovine serum as the circulating perfusate. Endotoxin was continuously injected at a fixed rate for 24 h, and perfusate endotoxin concentrations were measured at fixed time points. PMX-01R endotoxin adsorption was calculated from the difference in the endotoxin concentrations. Results: PMX-01R endotoxin adsorption increased continuously in a virtually linear manner. Conclusions: The PMX-01R column showed sustained endotoxin adsorption for at least 24 h. This indicated that PMX-F columns would be capable of clinical endotoxin removal for 24 h.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Karger AG, Basel"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0253-5068","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1159/000489920","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 The Author(s) Published by S. Karger AG, Basel"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamashita, Chizuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriyama, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Toshikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawaji, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimomura, Yasuyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurimoto, Yasuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Osamu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"R-2019-3_sakai.pdf","filesize":[{"value":"351.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2019-3_sakai.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6064/files/R-2019-3_sakai.pdf"},"version_id":"e41b5c2d-c65f-4545-95e2-da5b49ead3a2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Polymyxin B-immobilized fiber","subitem_subject_scheme":"Other"},{"subitem_subject":"Endotoxin adsorption","subitem_subject_scheme":"Other"},{"subitem_subject":"Continuous endotoxin injection","subitem_subject_scheme":"Other"},{"subitem_subject":"Adsorption saturation","subitem_subject_scheme":"Other"},{"subitem_subject":"24-h hemoperfusion","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymyxin B-immobilized fiber","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endotoxin adsorption","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Continuous endotoxin injection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adsorption saturation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"24-h hemoperfusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-26"},"publish_date":"2020-02-26","publish_status":"0","recid":"6064","relation_version_is_last":true,"title":["In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T07:48:24.008626+00:00"}