{"created":"2023-06-19T07:03:40.606097+00:00","id":6077,"links":{},"metadata":{"_buckets":{"deposit":"f15ae3d7-b247-46d9-b1bc-b2a4f71dd98d"},"_deposit":{"created_by":3,"id":"6077","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6077"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006077","sets":["9:27:28:29"]},"author_link":["19436","19437","19434","19438","4519","4715","19439","19435","4914","16387"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1455","bibliographicPageStart":"1450","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Robenacoxib is a novel nonsteroidal anti-inflammatory drug approved for dogs. The present study aimed to evaluate influences of sevoflurane anesthesia on the distribution of robenacoxib in dogs. Ten healthy beagle dogs (1 to 11 years old, 9.3 to 14.3 kg body weight, 6 males and 4 females) were subcutaneously administered robenacoxib (2 mg/kg) under conscious condition or sevoflurane anesthesia inhaled a 1.3-fold predetermined individual minimum alveolar concentration of sevoflurane at a 28-day interval. The dogs under sevoflurane anesthesia were also mechanically ventilated and received fluid-therapy. On each occasion, serum samples were collected from the dogs before and at 5, 15, 30, 60, 120, 180, and 240 min after the robenacoxib administration. Serum robenacoxib concentration was measured by a liquid chromatography-tandem mass spectrometry. Maximum serum concentration of robenacoxib (C_<max>) was 2.2 µg/ml [range: 1.2-4.6] (median [range: minimum-maximum]) and time of C_<max> (T_<max>) was 90 min [range: 60-120] in the conscious dogs. In the sevoflurane-anesthetized dogs, the C_<max> significantly declined (1.3 µg/ml [range: 0.8-1.4], P=0.008) and T_<max> was delayed (120 min [range: 120-240], P=0.018) compared with those in the conscious dogs. The serum robenacoxib concentration at 240 min (C_<240>) decreased to 0.5 µg/ml [range: 0.2-0.9] in the conscious dogs, while it remained higher in the sevoflurane-anesthetized dogs (1.0 µg/ml [range: 0.3-1.4], P=0.011). In conclusion, the anesthetic procedure with sevoflurane, mechanically ventilated, and received fluid-therapy might affect the pharmacokinetics of subcutaneously administered robenacoxib in dogs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1292/jvms.17-0356","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 The Japanese Society of Veterinary Science"}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OYAMA, Norihiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SANO, Tadashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAMORI, Mizuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAMURA, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UMAR, Mohammed Ahmed"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ENDO, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIKAWA, Yusyun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITOH, Akifumi"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"三好, 健二郎","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"YAMASHITA, Kazuto","creatorNameLang":"en"},{"creatorName":"山下, 和人","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"R-2019-49_oyama.pdf","filesize":[{"value":"790.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2019-49_oyama.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6077/files/R-2019-49_oyama.pdf"},"version_id":"eb1bc660-396a-4115-a616-237fd7a44d42"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dog","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"robenacoxib","subitem_subject_scheme":"Other"},{"subitem_subject":"sevoflurane","subitem_subject_scheme":"Other"},{"subitem_subject":"dog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"robenacoxib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sevoflurane","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-26"},"publish_date":"2020-02-26","publish_status":"0","recid":"6077","relation_version_is_last":true,"title":["Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:10:48.558558+00:00"}