{"created":"2023-06-19T07:03:42.048658+00:00","id":6111,"links":{},"metadata":{"_buckets":{"deposit":"0ee40e88-afa1-4c76-ad5b-7d4004988e30"},"_deposit":{"created_by":3,"id":"6111","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6111"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006111","sets":["9:27:33:34"]},"author_link":["5859","6295","19583","19584","19585"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"88","bibliographicPageStart":"82","bibliographicVolumeNumber":"839","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Modulation of cardiac contractility by α-adrenoceptor is well known in several mammals. Mice are useful experimental animals, but α-adrenoceptor-mediated responses have been examined only in the ventricles. To determine function of α-adrenoceptors in the atrium, effects of α-adrenoceptor agonists on spontaneous contraction and electrical-field stimulation (EFS)-induced contraction were examined. In addition, expression of α_<1A>, α_<1B>, α_<1D> and β_1-adrenoceptor mRNAs were examined. In the right atrium, noradrenaline and phenylephrine caused positive inotropic and positive chronotropic actions. However, methoxamine, clonidine and xylazine caused positive inotropic actions, but contractile frequency was decreased at high concentrations. Phenylephrine-induced positive inotropic and chronotropic actions were partially decreased by propranolol, and both actions remained in the presence of propranolol were inhibited by phentolamine or prazosin. A low concentration of silodosin (<100 nM) did not but a high concentration (1 μM) decreased the phenylephrine-induced chronotropic actions. Negative chronotropic actions of clonidine and xylazine were insensitive to propranolol and phentolamine. The EFS-induced contraction of the left atrium was potentiated by noradrenaline, phenylephrine and methoxamine but was not changed by clonidine or xylazine. Propranolol partially decreased the actions of phenylephrine, and prazosin caused additional inhibition. Expression of β_1^-, α_<1A>^-, α_<1B>^- and _<α1D>^-adrenoceptor mRNAs was found in the atrium, and the expression level of β_^1-adrenoceptor was the highest. Of α_1-adrenoceptors, the expression level of α_<1B> was higher than that of α_<1A> and α_<1D>. In conclusion, α_<1B>-adrenoceptors are expressed in the mouse atrium and mediate both positive chronotropic and inotropic actions. In contrast, the α_2^-adrenoceptor is not functional in the isolated atrium.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0014-2999","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ejphar.2018.08.038","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license."}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Shuangyi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Rena"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Natsumi"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"TERAOKA, Hiroki","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kitazawa, Takio"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"R-2019-144_kitazawa.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2019-144_kitazawa.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6111/files/R-2019-144_kitazawa.pdf"},"version_id":"16bf5fe9-c397-45f9-8aca-afc6f9cb5b51"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mouse atrium","subitem_subject_scheme":"Other"},{"subitem_subject":"Inotropic action","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronotropic action","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1^-adrenoceptor","subitem_subject_scheme":"Other"},{"subitem_subject":"α_<1B>^-adrenoceptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse atrium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inotropic action","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronotropic action","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1^-adrenoceptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α_<1B>^-adrenoceptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Αlpha_<1B>-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Αlpha_<1B>-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium"}]},"item_type_id":"2","owner":"3","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-26"},"publish_date":"2020-02-26","publish_status":"0","recid":"6111","relation_version_is_last":true,"title":["Αlpha_<1B>-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:22:54.043338+00:00"}