{"created":"2023-06-19T07:03:55.779749+00:00","id":6424,"links":{},"metadata":{"_buckets":{"deposit":"08194bee-30cd-4ee8-a7a5-37d5ab46f79a"},"_deposit":{"created_by":3,"id":"6424","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6424"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006424","sets":["9:27:28:29"]},"author_link":["5859","20556","6295","20555","16023"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"985","bibliographicPageStart":"983","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous polymorphic variants were identified in feline CYP2A13 in domestic cats in Japan, without an obvious major type. Metabolic parameters, Km and Vmax, of coumarin hydroxylation of CYP2A13 were shown to range within two times for the identified non-synonymous polymorphic variants by using heterologous coexpression system in Escherichia coli. The results confirmed the polymorphic nature of CYP2A13 as a basis for effective application of medicines and prevention of adverse reactions in treatment of domestic cats.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.19-0107","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUGIYAMA, Souta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UNO, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Amano, Tomoko","creatorNameLang":"en"},{"creatorName":"天野, 朋子","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KITAZAWA, Takio"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"TERAOKA, Hiroki","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-18"}],"displaytype":"detail","filename":"R-2020-172_teraoka.pdf","filesize":[{"value":"726.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2020-172_teraoka.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6424/files/R-2020-172_teraoka.pdf"},"version_id":"8b0d9d0b-020e-42ef-a8b2-5a9b4e44686b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cytochrome P450","subitem_subject_scheme":"Other"},{"subitem_subject":"domestic cat","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"xenobiotic","subitem_subject_scheme":"Other"},{"subitem_subject":"cytochrome P450","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"domestic cat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"xenobiotic","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-18"},"publish_date":"2020-11-18","publish_status":"0","recid":"6424","relation_version_is_last":true,"title":["Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:22:44.661647+00:00"}