{"created":"2023-06-19T07:03:56.512724+00:00","id":6441,"links":{},"metadata":{"_buckets":{"deposit":"acb27947-78b7-4273-8138-472cc1253135"},"_deposit":{"created_by":3,"id":"6441","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6441"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006441","sets":["9:27:28:29"]},"author_link":["20634","4653","4638","16162","20633","20632","20636","20635"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"67","bibliographicPageStart":"64","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Animal Models and Experimental Medicine"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adult T‐cell leukemia (ATL) is a mature T‐cell malignancy caused by human T‐cell leukemia virus type I infection, and 10%‐25% of patients show central nervous system (CNS) involvement. CNS involvement significantly reduces survival and there are no effective treatments for CNS involvement. Therefore, an appropriate animal model is required to evaluate the inhibitory effects of novel drugs on the progression of ATL with CNS involvement. Here, we established a mouse model of ATL with CNS involvement using NOD.Cg‐Prkdc^<scid>Il2rg^<tm1Wjl>/SzJ mice inoculated with ATL cells intramuscularly in the postauricular region, and these mice showed paraparesis. Of the 10 mice inoculated with ATL cells intramuscularly (I.M.) at 5 weeks of age, 8 (80%) showed paraparesis, whereas none of the 10 mice inoculated with ATL cells subcutaneously (S.C.) showed paraparesis. In the I.M. group, PCR detected HTLV‐1‐specific genes in the thoracic and lumbar vertebrae; however, in the S.C. group, the vertebrae were negative for HTLV‐1 genes. Histological analysis revealed a particularly high incidence of tumors, characterized by accumulation of the injected cells, in the thoracic vertebrae of mice in the I.M. group. Tumor cell infiltration was relatively high in the bone marrow. Spinal cord compression caused by invasion of the tumor mass outside the pia mater was observed in the thoracic vertebrae of the spinal cord. In conclusion, we have reported a mouse model of tumor growth with paraparesis that may be used to assess novel therapeutic agents for ATL with CNS involvement.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Inc."}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2096-5451","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/ame2.12053","subitem_relation_type_select":"DOI"}}]},"item_2_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences"}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by-nc/4.0/ | http://creativecommons.org/licenses/by-nc/4.0/"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohsugi, Takeo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Shuhei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasaki, Keigo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagano, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kozako, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"MATSUDA, Kazuya","creatorNameLang":"en"},{"creatorName":"松田, 一哉","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hirose, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takehana, Kazushige"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-18"}],"displaytype":"detail","filename":"R-2020-210_oosugi.pdf","filesize":[{"value":"883.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2020-210_oosugi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6441/files/R-2020-210_oosugi.pdf"},"version_id":"d546538c-160e-44c5-8ab7-d2ed75eded21"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adult T-cell leukemia (ATL)","subitem_subject_scheme":"Other"},{"subitem_subject":"central nervous system (CNS)","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1)","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_scheme":"Other"},{"subitem_subject":"NOD.Cg-Prkdc^<scid>Il2rg^<tm1Wjl>/SzJ mice","subitem_subject_scheme":"Other"},{"subitem_subject":"adult T-cell leukemia (ATL)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"central nervous system (CNS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NOD.Cg-Prkdc^<scid>Il2rg^<tm1Wjl>/SzJ mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-18"},"publish_date":"2020-11-18","publish_status":"0","recid":"6441","relation_version_is_last":true,"title":["A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:50:19.793812+00:00"}