{"created":"2023-06-19T07:04:11.537014+00:00","id":6756,"links":{},"metadata":{"_buckets":{"deposit":"38f04861-ec61-4be5-8b7a-54b217420643"},"_deposit":{"created_by":3,"id":"6756","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6756"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006756","sets":["9:27:28:29"]},"author_link":["21873","21874","21875","19434","4715","20647","21876","4914"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"61","bibliographicPageStart":"53","bibliographicVolumeNumber":"83","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We aimed to evaluate the induction, anesthesia, and cardiorespiratory effects of intramuscular (IM) anesthetic protocol with alfaxalone following premedication with low-dose medetomidine, butorphanol, or a combination of both (medetomidine-butorphanol) in dogs. Six healthy beagles were administered 1, 2.5, or 5 mg/kg alfaxalone IM following premedication with low-dose medetomidine (5 μg/kg; MA-IM), butorphanol (0.3 mg/kg; BA-IM), or medetomidinebutorphanol (5 μg/kg and 0.3 mg/kg, respectively; MBA-IM). Each dog received 9 treatments with minimum 7-day washout period between treatments. Dogs were allowed to breath room air during anesthetic induction. We attempted endotracheal intubation after alfaxalone administration. Alfaxalone produced a dose-dependent anesthetic effect in each anesthetic protocol. Intubation was achieved in 4 out of 6 dogs that received MA-IM and BA-IM with 2.5 mg/kg alfaxalone and in all dogs that received MBA-IM with 1, 2.5, and 5 mg/kg alfaxalone. The median durations [minimum-maximum] of accepting intubation were 79 [0-89], 97 [84-120], and 117 [84-217] min, respectively. Hypotension (mean arterial blood pressure <60 mmHg) did not develop, but bradycardia (heart rate <60 beats/min) was observed in all dogs that received the MA-IM and MBA-IM protocols. Severe hypoxemia (percutaneous arterial oxygen saturation <90%) developed in 2 dogs that received MBA-IM with 5 mg/kg alfaxalone. We consider that the MA-IM and BA-IM protocols with ≥2.5 mg/kg alfaxalone and the MBA-IM protocol with 1-2.5 mg/kg alfaxalone could provide clinically useful and effective anesthesia without causing severe cardiorespiratory depression in healthy dogs.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.20-0330","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATO, Keiko"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"ITAMI, Takaharu","creatorNameLang":"en"},{"creatorName":"伊丹, 貴晴","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NOMOTO, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ENDO, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAMURA, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OYAMA, Norihiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SANO, Tadashi"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"YAMASHITA, Kazuto","creatorNameLang":"en"},{"creatorName":"山下, 和人","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"R-2021-27_itami.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2021-27_itami.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6756/files/R-2021-27_itami.pdf"},"version_id":"a6b8f36a-383a-4710-83c5-aa22afb768ed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alfaxalone","subitem_subject_scheme":"Other"},{"subitem_subject":"butorphanol","subitem_subject_scheme":"Other"},{"subitem_subject":"dog","subitem_subject_scheme":"Other"},{"subitem_subject":"intramuscular anesthesia","subitem_subject_scheme":"Other"},{"subitem_subject":"medetomidine","subitem_subject_scheme":"Other"},{"subitem_subject":"alfaxalone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"butorphanol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intramuscular anesthesia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medetomidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The anesthetic effects of intramuscular alfaxalone in dogs premedicated with low-dose medetomidine and/or butorphanol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The anesthetic effects of intramuscular alfaxalone in dogs premedicated with low-dose medetomidine and/or butorphanol"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"6756","relation_version_is_last":true,"title":["The anesthetic effects of intramuscular alfaxalone in dogs premedicated with low-dose medetomidine and/or butorphanol"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:15:56.002449+00:00"}