{"created":"2023-06-19T07:04:12.060690+00:00","id":6768,"links":{},"metadata":{"_buckets":{"deposit":"072dc44e-ec4d-47af-9b21-e2ff0c9d1a7e"},"_deposit":{"created_by":3,"id":"6768","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6768"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006768","sets":["9:27:28:29"]},"author_link":["21929","21863","4528","21927","21928","4494","21930"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1749","bibliographicPageStart":"1742","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aimed to evaluate innate immune responses of mammary glands induced by intramammary infusion of Bifidobacterium breve in dairy cows. Somatic cell counts in quarters of cows showed a marked increase following B. breve infusion on days 1 and 2. Opsonizedstimulated chemiluminescence response in quarter milk was significantly (P<0.05) increased by B. breve infusion on days 1 to 3 compared to that of pre-infusion. Lactoferrin concentrations in B. breve-infused quarter milk increased significantly (P<0.05) on days 2 to 4 and 6 compared to those of pre-infusion. IgG and IgA concentrations in B. breve-infused quarters significantly (P<0.05) increased on days 2 to 4 for IgG and days 3, 4, 6 and 8 for IgA compared to those of pre-infusion. Interleukin (IL)-1β and IL-8 mRNA levels in somatic cells from B. breve-infused quarters were significantly (P<0.05) upregulated on day 1 compared to those on days 0 and 14. Conversely, IL-6 mRNA levels in somatic cells from B. breve-infused quarters on days 0, 1 and 14 and NF-κB mRNA levels on day 0 were significantly (P<0.05) down-regulated compared to those of control. IL-1β, tumor necrosis factor (TNF)-α and IL-6 concentrations increased on days 1, 3 and 7 after B. breve infusion in quarters. Intramammary infusion of B. breve (3 × 109 cfu) induces a massive influx of leukocytes and enhances innate immune response in mammary glands. This event may contribute to the enhancing host defense in the mammary gland.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_relation_11":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"0916-7250","subitem_relation_type_select":"ISBN"}}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.20-0273","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAGAHATA, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MORIYAMA, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAWADA, Chika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ASAI, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOKUBU, Chihiro"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Gondaira, Satoshi","creatorNameLang":"en"},{"creatorName":"権平, 智","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"樋口, 豪紀","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"R-2021-56_higuchi.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2021-56_higuchi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6768/files/R-2021-56_higuchi.pdf"},"version_id":"112a8550-a6ff-4dcc-9af0-7da1dd977a23"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bifidobacterium breve","subitem_subject_scheme":"Other"},{"subitem_subject":"dairy cow","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"intramammary infusion","subitem_subject_scheme":"Other"},{"subitem_subject":"Bifidobacterium breve","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dairy cow","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intramammary infusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Innate immune response of mammary gland induced by intramammary infusion of Bifidobacterium breve in lactating dairy cows","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Innate immune response of mammary gland induced by intramammary infusion of Bifidobacterium breve in lactating dairy cows"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"6768","relation_version_is_last":true,"title":["Innate immune response of mammary gland induced by intramammary infusion of Bifidobacterium breve in lactating dairy cows"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:07:28.020816+00:00"}