{"created":"2023-06-19T07:04:14.694011+00:00","id":6830,"links":{},"metadata":{"_buckets":{"deposit":"9b89b6fc-bda2-465a-b572-62c193ff961d"},"_deposit":{"created_by":3,"id":"6830","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6830"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006830","sets":["9:27:28:29"]},"author_link":["4684","4683","4758","22214","22213","22218","22217","22216","22215"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"33","bibliographicPageStart":"13","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Food Safety"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Colistin is a critically important antibiotic for humans. The Japanese government withdrew colistin growth promoter and shifted therapeutic colistin to a second-choice drug for pigs in 2017. A quantitative release assessment of mcr-mediated colistin-resistant Escherichia coli (E. coli) in Japanese finisher pigs was conducted under the World Organisation for Animal Health (OIE) risk assessment framework. Input data included colistin resistance and mcr-1-5 test results for E. coli isolates in the Japan Veterinary Resistance Monitoring System (JVARM), postal survey results regarding indication disease occurrence and colistin use by swine veterinarians in 2017 and 2018, and colistin resistance and mcr monitoring experiments at four pig farms in 2017-2018. An individual-based model was developed to assess the risk: the proportion of Japanese finisher pigs with mcr-1-5-mediated colistin-resistant E. coli dominant in the gut on an arbitrary day. Before implementing risk management measures, the risk was estimated to be 5.5% (95% CI: 4.2%-10.1%). At 12 months after stopping colistin growth promoter, the proportion of pigs with plasmid-mediated colistin-resistant E. coli declined by 52.5% on the experiment farms (95% CI: 8.7%-80.8%). The probability of therapeutic colistin use at the occurrence of bacterial diarrhea declined from 37.3% (95% CI: 30.3%-42.5%) in 2017 to 31.4% (95% CI: 26.1%-36.9%), and that of edema disease declined from 55.0% (95% CI: 46.0%-63.7%) to 44.4% (95% CI: 36.9%-52.0%). After risk management implementation, the risk was estimated to have declined to 2.3% (95% CI: 1.8%-4.3%; 58.2% reduction). Scenario analyses showed that pen-level colistin treatment effectively reduces the risk from 5.5% to 4.7% (14.5% reduction), an effect similar to stoppage of therapeutic colistin (16.4% reduction to 4.6%).","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Food Safety Commission"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.14252/foodsafetyfscj.D-20-00004","subitem_relation_type_select":"DOI"}}]},"item_2_rights_16":{"attribute_name":"権利（URI）","attribute_value_mlt":[{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/deed.ja | https://creativecommons.org/licenses/by/4.0/deed.ja"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"MAKITA, Kohei","creatorNameLang":"en"},{"creatorName":"蒔田, 浩平","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fujimoto, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugahara, Nami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyama, Takeshi"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"USUI, Masaru","creatorNameLang":"en"},{"creatorName":"臼井, 優","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Asai, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawanishi, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozawa, Manao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamura, Yutaka"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-21"}],"displaytype":"detail","filename":"R-2021-255_makita.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2021-255_makita.pdf","url":"https://rakuno.repo.nii.ac.jp/record/6830/files/R-2021-255_makita.pdf"},"version_id":"ef431cc9-931c-497e-9612-70f25d81dafc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colistin","subitem_subject_scheme":"Other"},{"subitem_subject":"mcr","subitem_subject_scheme":"Other"},{"subitem_subject":"quantitative risk assessment","subitem_subject_scheme":"Other"},{"subitem_subject":"colistin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mcr","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quantitative risk assessment","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quantitative Release Assessment of mcr-mediated Colistin-resistant Escherichia Coli from Japanese Pigs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantitative Release Assessment of mcr-mediated Colistin-resistant Escherichia Coli from Japanese Pigs"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"6830","relation_version_is_last":true,"title":["Quantitative Release Assessment of mcr-mediated Colistin-resistant Escherichia Coli from Japanese Pigs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:58:18.954846+00:00"}