{"created":"2023-06-19T07:04:14.736605+00:00","id":6831,"links":{},"metadata":{"_buckets":{"deposit":"8ceb515c-4953-4242-8e1f-90ed038341d3"},"_deposit":{"created_by":3,"id":"6831","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6831"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00006831","sets":["9:27:28:29"]},"author_link":["22220","22219","22222","22221"],"item_2_alternative_title_22":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Bovine mycoplasmosis"}]},"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"176","bibliographicPageStart":"170","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"産業動物臨床医学雑誌"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ウシのマイコプラズマ感染症，特にMycoplasma bovisは畜産業において最も重要な病原体である．まずM. bovisの病原性について，近年の技術革新により全ゲノム解析が活発に実施されるようになってきており，遺伝子レベルだけでなく，プロテオーム解析からもその病原性因子が明らかにされつつある．次に，M. bovisと宿主との相互作用について，M. bovis感染により炎症促進性サイトカインが白血球，乳腺上皮細胞または滑膜細胞から産生され病態悪化の一因を担っている．また，M. bovisは宿主の細胞死を調整し，さらに，宿主の白血球に免疫疲弊化を惹起させる．　治療および予防戦略について，M. bovisの薬剤耐性菌株が日本国内でも分離されており，薬剤の適正使用が求められている．また，M. bovis感染症のリスク要因が疫学的研究により明らかにされてきており，適切な飼養環境のもとで検査による予防対策が重要である。","subitem_description_type":"Abstract"},{"subitem_description":"Mycoplasma infectious diseases in cattle, especially Mycoplasma bovis are one of the most important pathogens in the livestock industry. Regarding the pathogenicity of M. bovis, recent technological innovations have actively carried out whole-genome analysis to clarify the pathogenic factors at the gene level, and further, proteome analysis has revealed pathogenic proteins. Regarding the host’s immune response by M. bovis, pro-inflammatory cytokines are produced from leukocytes, bovine mammary epithelial cells, and synovial cells and play an important role in worsening of condition. In addition, M. bovis affects the functional expression of the host, regulates cell death, and induces immune exhaustion of the host. Regarding treatment and prevention strategies, since antimicrobial resistance M. bovis have been isolated in Japan, careful use of antibiotics is required. The risk factors for M. bovis infectious disease have been clarified by epidemiological studies, and preventive measures by M. bovis specific detection tests under an appropriate management are important.","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"22221","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"329f5f9cbe394bf960392a0d922b9077","nameIdentifierScheme":"教員総覧","nameIdentifierURI":"http://souran.rakuno.ac.jp/profile/ja.329f5f9cbe394bf960392a0d922b9077.html"}],"names":[{"name":"Gondaira, Satoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"22222","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"7c44f3b474ba13b6","nameIdentifierScheme":"教員総覧","nameIdentifierURI":"http://souran.rakuno.ac.jp/profile/ja.7c44f3b474ba13b6.html"}],"names":[{"name":"Higuchi, Hidetoshi"}]}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本家畜臨床学会 ・ 大動物臨床研究会"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"権平, 智"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"樋口, 豪紀"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-06"}],"displaytype":"detail","filename":"R-2021-264_gondaira.pdf","filesize":[{"value":"425.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"R-2021-264_gondaira","url":"https://rakuno.repo.nii.ac.jp/record/6831/files/R-2021-264_gondaira.pdf"},"version_id":"11995806-6f54-4f8e-81fc-f5a96da84eaa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mycoplasma bovis","subitem_subject_scheme":"Other"},{"subitem_subject":"病原性因子","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫応答","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制機構","subitem_subject_scheme":"Other"},{"subitem_subject":"予防","subitem_subject_scheme":"Other"},{"subitem_subject":"virulence factors","subitem_subject_scheme":"Other"},{"subitem_subject":"immune response","subitem_subject_scheme":"Other"},{"subitem_subject":"immunosuppressive mechanism","subitem_subject_scheme":"Other"},{"subitem_subject":"preventive hygiene","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ウシのマイコプラズマ感染症","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウシのマイコプラズマ感染症"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-21"},"publish_date":"2022-02-21","publish_status":"0","recid":"6831","relation_version_is_last":true,"title":["ウシのマイコプラズマ感染症"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:31:40.307521+00:00"}