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Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer
http://hdl.handle.net/10659/3036
http://hdl.handle.net/10659/3036d90ad951-05e6-4f9a-ae2e-96128426f6e5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-04 | |||||
| タイトル | ||||||
| タイトル | Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Aging | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Canine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lymphocyte subsets | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumor stages | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumor types | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watabe, Ai
× Watabe, Ai× Fukumoto, Shinya× Komatsu, Takahiro× Endo, Yoshifumi× Kadosawa, Tsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in an individual's immune status are considered major contributing factors towards the morbidity of cancer and mortality of aging. To evaluate age-related changes in the immune status of dogs, the immunophenotypes (CD3, CD4, CD8 and CD21) of peripheral blood lymphocytes were measured in 160 healthy dogs aged from 1 to 17 years, and in 365 dogs with various tumors and at various stages. In healthy dogs, the absolute numbers of white blood cells, lymphocytes, and CD3^+, CD4^+ and CD21^+ lymphocytes decreased significantly with age. The relative percentages of lymphocytes and CD4^+ cells decreased significantly, while CD8^+ cells increased significantly with age. The CD4:CD8 ratio showed a significant age-related decrease. In contrast, dogs with tumors possessed significantly lower absolute numbers and relative percentages of all lymphocyte phenotypes, while the CD4:CD8 ratio was significantly higher than in age-matched controls. The relative percentages of CD3^+ and CD8^+ lymphocytes were significantly lower in dogs with distant metastases compared with dogs without metastases, and the CD4:CD8 ratio increased with advanced stage. These observations illustrate the significant changes in immune status with age and the presence of marked immunological defects in a large-scale study of dogs with advanced tumors. | |||||
| 書誌情報 |
Veterinary Immunology and Immunopathology 巻 142, 号 3-4, p. 189-200, 発行日 2011-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0165-2427 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.vetimm.2011.05.008 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
