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Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma bearing mice

http://hdl.handle.net/10659/1822
http://hdl.handle.net/10659/1822
03b5ef99-f7a9-403e-a8af-20c120958eee
名前 / ファイル ライセンス アクション
S-553_Suzuki.pdf S-553_Suzuki.pdf (120.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-03-31
タイトル
タイトル Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma bearing mice
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Sakurai, Noritaka

× Sakurai, Noritaka

WEKO 5460

Sakurai, Noritaka

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Suzuki, Kazuyuki

× Suzuki, Kazuyuki

WEKO 5461

Suzuki, Kazuyuki

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Sano, Yuki

× Sano, Yuki

WEKO 5462

Sano, Yuki

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Saito, Teruyoshi

× Saito, Teruyoshi

WEKO 5463

Saito, Teruyoshi

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Yoshimura, Hisashi

× Yoshimura, Hisashi

WEKO 5464

Yoshimura, Hisashi

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Nishimura, Yukie

× Nishimura, Yukie

WEKO 5465

Nishimura, Yukie

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Yano, Tomohiro

× Yano, Tomohiro

WEKO 5466

Yano, Tomohiro

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Sadzuka, Yasuyuki

× Sadzuka, Yasuyuki

WEKO 5467

Sadzuka, Yasuyuki

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Asano, Ryuji

× Asano, Ryuji

WEKO 5468

Asano, Ryuji

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抄録
内容記述タイプ Abstract
内容記述 The present study was designed to investigate the effects of Bowman-Birk inhibitor concentrate (BBIC) on anti-proliferation, up-regulation of Connexin 43 (Cx43) expression and inhabitation of hepatic metastasis in mice with M5076 ovarian sarcoma. M5076 ovarian sarcomas (1x10^6 cells/animal) were subcutaneously transplanted into the back of BDF_1 mice. The ‘pre-treated’ (n=10) and ‘post-treated’ (n=10) groups were fed a standard diet (CE-2) compounded with 0.5% BBI from 3 weeks before and from the day of tumor inoculation, respectively, until 4 weeks after tumor inoculation. The ‘control group’ (n=10) was fed CE-2 alone. Relative tumor weights in the pre- (0.013±0.010) and post- (0.012±0.013) treated groups were significantly reduced by 30.0 and 32.5%, respectively, as compared to the control group (0.040±0.022, p<0.01). The relative densities of Cx43 mRNA and Cx43 protein were significantly higher in the BBIC-treated groups than in the control group. The median numbers of macroscopic spontaneous metastases were significantly lower in the pre- (1.0±2.3) and post- (1.9±3.6) treated groups than in the control group (71.4±97.3). These results suggest that BBIC reduces proliferation as a result of increased expression of Cx43 genes in mice with M5076 ovarian sarcoma. In addition, BBIC inhibits hepatic metastasis in M5076-bearing mice.
書誌情報 Molecular Medicine Reports

巻 1, 号 6, p. 903-907, 発行日 2008-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 1791-2997
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.3892/mmr_00000048
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 Spandidos Publications
資源タイプ
内容記述タイプ Other
内容記述 Article
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