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Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis
http://hdl.handle.net/10659/1777
http://hdl.handle.net/10659/1777595a1e8d-510f-4dbf-9af5-12117519df96
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-539_Takehana.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-03-31 | |||||
| タイトル | ||||||
| タイトル | Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
NAGAYASU, Aya
× NAGAYASU, Aya× NAKAMURA, Taito× YAMATO, Osamu× TSUZUKI, Keiko× HOSAKA, Yoshinao× 植田, 弘美× TANGKAWATTANA, Prasarn× TAKEHANA, Kazushige |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | GM1 gangliosidosis is one of the inherited metabolic lysosomal storage disorders characterized by neurological symptoms caused by β-galactosidase deficiency and consequent accumulation of GM1 ganglioside in neuronal cells. Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of neutral carbohydrates, resulting in the loss of normal arrangement of collagen fibrils in the opaque cornea was found to be associated with the disorder. We therefore conclude that corneal opacity in this Shiba dog with GM1 gangliosidosis may be caused by neutral carbohydrate accumulation in lysosomes, swelling and dysfunction of keratocytes, and subsequent irregular arrangement of collagen fibrils in the corneal proper substance. | |||||
| 書誌情報 |
The journal of veterinary medical science 巻 70, 号 9, p. 881-886, 発行日 2008-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.70.881 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
