WEKO3
アイテム
{"_buckets": {"deposit": "f55fbe52-2150-4cf1-97a8-3ab601451869"}, "_deposit": {"created_by": 3, "id": "2390", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2390"}, "status": "published"}, "_oai": {"id": "oai:rakuno.repo.nii.ac.jp:00002390", "sets": ["29"]}, "author_link": ["6977", "6981", "6978", "6979", "6980"], "item_2_biblio_info_9": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-10", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "349751-7", "bibliographicPageStart": "349751-1", "bibliographicVolumeNumber": "2015", "bibliographic_titles": [{"bibliographic_title": "Evidence-Based Complementary and Alternative Medicine"}]}]}, "item_2_description_43": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_2_description_6": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Myoblast activation is a triggering event for muscle remodeling. We assessed the stimulatory effects of propolis, a beehive product, on myoblasts. After an 8 h treatment with 100 μg/mL of Brazilian propolis ethanol extract, expression of various chemokines, including CCL-2 and CCL-5, and cytokines, such as IL-6, increased. This propolis-induced cytokine production appears to depend on NF-κB activation, because the IKK inhibitor BMS-345541 repressed mRNA levels of CCL-2 by ~66%, CCL-5 by ~81%, and IL-6 by ~69% after propolis treatment. Supernatant from propolis-conditioned C2C12 cells upregulated RAW264 macrophage migration. The supernatant also stimulated RAW264 cells to produce angiogenic factors, including VEGF-A and MMP-12. Brazilian green propolis therefore causes myoblasts to secrete cytokines and chemokines, which might contribute to tissue remodeling of skeletal muscle.", "subitem_description_type": "Abstract"}]}, "item_2_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Hindawi Publishing Corporation"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1155/2015/349751", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2015 Kohei Washio et al."}, {"subitem_rights": "This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_2_rights_16": {"attribute_name": "権利(URI)", "attribute_value_mlt": [{"subitem_rights": "https://creativecommons.org/licenses/by/3.0/ | https://creativecommons.org/licenses/by/3.0/"}]}, "item_2_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Washio, Kohei"}], "nameIdentifiers": [{"nameIdentifier": "6977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Mao"}], "nameIdentifiers": [{"nameIdentifier": "6978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Natsuko"}], "nameIdentifiers": [{"nameIdentifier": "6979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amagasa, Misato"}], "nameIdentifiers": [{"nameIdentifier": "6980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "6981", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "S-2016-158_kitamura.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "S-2016-158_kitamura.pdf", "url": "https://rakuno.repo.nii.ac.jp/record/2390/files/S-2016-158_kitamura.pdf"}, "version_id": "d079e2fe-d63c-4d67-bafe-5e97d17ed330"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts"}]}, "item_type_id": "2", "owner": "3", "path": ["29"], "permalink_uri": "http://hdl.handle.net/10659/4989", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-06-09"}, "publish_date": "2017-06-09", "publish_status": "0", "recid": "2390", "relation": {}, "relation_version_is_last": true, "title": ["Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts"], "weko_shared_id": -1}
Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts
http://hdl.handle.net/10659/4989
http://hdl.handle.net/10659/4989e73eebda-8cc2-4395-8d34-65d7cbd52a96
名前 / ファイル | ライセンス | アクション |
---|---|---|
S-2016-158_kitamura.pdf (2.0 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-06-09 | |||||
タイトル | ||||||
タイトル | Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Washio, Kohei
× Washio, Kohei× Kobayashi, Mao× Saito, Natsuko× Amagasa, Misato× Kitamura, Hiroshi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myoblast activation is a triggering event for muscle remodeling. We assessed the stimulatory effects of propolis, a beehive product, on myoblasts. After an 8 h treatment with 100 μg/mL of Brazilian propolis ethanol extract, expression of various chemokines, including CCL-2 and CCL-5, and cytokines, such as IL-6, increased. This propolis-induced cytokine production appears to depend on NF-κB activation, because the IKK inhibitor BMS-345541 repressed mRNA levels of CCL-2 by ~66%, CCL-5 by ~81%, and IL-6 by ~69% after propolis treatment. Supernatant from propolis-conditioned C2C12 cells upregulated RAW264 macrophage migration. The supernatant also stimulated RAW264 cells to produce angiogenic factors, including VEGF-A and MMP-12. Brazilian green propolis therefore causes myoblasts to secrete cytokines and chemokines, which might contribute to tissue remodeling of skeletal muscle. | |||||
書誌情報 |
Evidence-Based Complementary and Alternative Medicine 巻 2015, p. 349751-1-349751-7, 発行日 2015-10 |
|||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2015/349751 | |||||
権利 | ||||||
権利情報 | Copyright © 2015 Kohei Washio et al. | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by/3.0/ | https://creativecommons.org/licenses/by/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |