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Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice
http://hdl.handle.net/10659/4307
http://hdl.handle.net/10659/4307a9e1e18d-b56b-4ca1-897d-18cea3a727fa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2015-170_osugi.pdf (103.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-05-23 | |||||
| タイトル | ||||||
| タイトル | Stevens-Johnson syndrome/toxic epidermal necrolysis-like disease in human T-cell leukemia virus type 1 Tax transgenic mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | SJS-TEN | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HTLV-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ATLL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tax | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transgenic mice | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ohsugi, Takeo
× Ohsugi, Takeo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Human T-cell leukemia virus type 1 (HTLV-1) can cause adult T-cell leukemia/lymphoma (ATLL) and inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). My research group established a transgenic (Tg) mouse model of HTLV-1 infection using the distal promoter of Lck to induce tax expression in mature thymocytes and peripheral T lymphocytes. The major disease phenotypes in this model were mature T cell leukemia/lymphoma, similar to ATLL, and inflammatory arthropathy. While expanding Tax-Tg mouse colony, my group found that about 2% of the Tg mice developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)-like disease. SJS/TEN-like lesions were characterized by a rash and diffuse exfoliation of large areas of the skin, similar to second-degree burns. The pathology of Tg mice with SJS/TEN-like disease included epidermal necrosis and detachment at the dermoepidermal junction. Serum soluble Fas ligand levels were significantly increased in Tax-Tg mice with SJS/TEN-like disease. | |||||
| 書誌情報 |
Current Trends in Immunology 巻 15, p. 43-46, 発行日 2014-12 |
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| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Research Trends | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
