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Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma
http://hdl.handle.net/10659/00005380
http://hdl.handle.net/10659/000053805b93a579-7d2c-4697-a854-6db3e84564bb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2017-35_Adachi.pdf (2.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-12 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | canine hemangiosarcoma dog | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MAPK pathway | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PI3K/Akt/m-TOR pathway | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | receptor tyrosine kinase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
ADACHI, Mami
× ADACHI, Mami× HOSHINO, Yuki× IZUMI, Yusuke× TAKAGI, Satoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA. | |||||
| 書誌情報 |
The Journal of veterinary medical science 巻 78, 号 4, p. 649-656, 発行日 2016-04 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1292/jvms.15-0625 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
