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Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats
http://hdl.handle.net/10659/00006657
http://hdl.handle.net/10659/000066571d41aaf5-e6bc-4cfa-9a6c-3cd97c237a3d
名前 / ファイル | ライセンス | アクション |
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R-2020-172_teraoka.pdf (726.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-18 | |||||
タイトル | ||||||
タイトル | Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytochrome P450 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | domestic cat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | xenobiotic | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cytochrome P450 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | domestic cat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | xenobiotic | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SUGIYAMA, Souta
× SUGIYAMA, Souta× UNO, Yasuhiro× 天野, 朋子× KITAZAWA, Takio× TERAOKA, Hiroki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous polymorphic variants were identified in feline CYP2A13 in domestic cats in Japan, without an obvious major type. Metabolic parameters, Km and Vmax, of coumarin hydroxylation of CYP2A13 were shown to range within two times for the identified non-synonymous polymorphic variants by using heterologous coexpression system in Escherichia coli. The results confirmed the polymorphic nature of CYP2A13 as a basis for effective application of medicines and prevention of adverse reactions in treatment of domestic cats. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 81, 号 7, p. 983-985, 発行日 2019-07 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1292/jvms.19-0107 | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |