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The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs
http://hdl.handle.net/10659/4991
http://hdl.handle.net/10659/4991351924eb-5e58-4041-a5be-8979c4982bab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2016-187_yamashita.pdf (554.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-06-09 | |||||
| タイトル | ||||||
| タイトル | The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | alfaxalone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anesthetic effect | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | canine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intramuscular | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
TAMURA, Jun
× TAMURA, Jun× ISHIZUKA, Tomohito× FUKUI, Sho× OYAMA, Norihiko× KAWASE, Kodai× 三好, 健二郎× SANO, Tadashi× PASLOSKE, Kirby× 山下, 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) administration to 6 healthy beagle dogs. The dogs received three IM doses each of alfaxalone at increasing dose rates of 5 mg/kg (IM5), 7.5 mg/kg (IM7.5) and 10 mg/kg (IM10) every other day. Anesthetic effect was subjectively evaluated by using an ordinal scoring system to determine the degree of neuro-depression and the quality of anesthetic induction and recovery from anesthesia. Cardiorespiratory variables were measured using noninvasive methods. Alfaxalone administered IM produced dose-dependent neuro-depression and lateral recumbency (i.e., 36 ± 28 min, 87 ± 26 min and 115 ± 29 min after the IM5, IM7.5 and IM10 treatments, respectively). The endotracheal tube was tolerated in all dogs for 46 ± 20 and 58 ± 21 min after the IM7.5 and IM10 treatments, respectively. It was not possible to place endotracheal tubes in 5 of the 6 dogs after the IM5 treatment. Most cardiorespiratory variables remained within clinically acceptable ranges, but hypoxemia was observed by pulse oximetry for 5 to 10 min in 2 dogs receiving the IM10 treatment. Dose-dependent decreases in rectal temperature, respiratory rate and arterial blood pressure also occurred. The quality of recovery was considered satisfactory in all dogs receiving each treatment; all the dog exhibited transient muscular tremors and staggering gait. In conclusion, IM alfaxalone produced a dose-dependent anesthetic effect with relatively mild cardiorespiratory depression in dogs. However, hypoxemia may occur at higher IM doses of alfaxalone. | |||||
| 書誌情報 |
The Journal of Veterinary Medical Science 巻 77, 号 3, p. 289-296, 発行日 2015-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.14-0368 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
