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Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development
http://hdl.handle.net/10659/4981
http://hdl.handle.net/10659/4981a109c4c3-0334-4098-bfc9-4f24f2eeafa3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2016-205_yokota.pdf (679.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-06-09 | |||||
| タイトル | ||||||
| タイトル | Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bisphenol A | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bisphenol AF | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bisphenol F | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | UDP glucuronosyl transferase (UGT) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
YABUSAKI, Risa
× YABUSAKI, Risa× 岩野, 英知× TSUSHIMA, Sumito× KOIKE, Nanako× OHTANI, Naoko× TANEMURA, Kentaro× INOUE, Hiroki× YOKOTA, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this effective metabolizing system is weak in the fetus. In the present study, we demonstrated that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the fetus and newborn pups, and was increased to the same level as BPA post-partum. In conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism during the perinatal period, suggesting that the metabolism of individual Bisphenol analogs requires assessment to properly gauge their risks. | |||||
| 書誌情報 |
The Journal of Veterinary Medical Science 巻 77, 号 11, p. 1479-1484, 発行日 2015-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.15-0197 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
