WEKO3
アイテム
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The aim of this study was to characterize muscarinic receptors involved in regulation of colonic contractility. M_2 and/or M_3 receptor knockout (KO) and wild-type mice were used in in vivo (defecation, colonic propulsion) and in vitro (contraction) experiments. Amount of feces was significantly decreased in M_3R-KO and M_2/M_3R-KO mice but not in M_2R-KO mice. Ranking of colonic propulsion was wild-type = M_2R-KO \u003e M_3R-KO \u003e M_2/M_3R-KO. In vitro, the amplitude of migrating motor complexes in M_2R-KO, M_3R-KO and M_2/M_3R-KO mice was significantly lower than that in wild-type mice. Carbachol caused concentration-dependent contraction of the proximal colon and distal colon from wild-type mice. In M_2R-KO mice, the concentration-contraction curves shifted to the right and downward. In contrast, carbachol caused non-sustained contraction and relaxation in M_3R-KO mice depending on its concentration. 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Muscarinic receptor subtypes involved in regulation of colonic motility in mice: Functional studies using muscarinic receptor-deficient mice
http://hdl.handle.net/10659/2973
http://hdl.handle.net/10659/2973379c5173-eb0e-4e4f-9c04-4f2060ea211d
名前 / ファイル | ライセンス | アクション |
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S-2012-151_kitazawa.pdf (662.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Muscarinic receptor subtypes involved in regulation of colonic motility in mice: Functional studies using muscarinic receptor-deficient mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mouse colon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Muscarinic receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Knockout mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nitrergic nerve | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kondo, Takaji
× Kondo, Takaji× Nakajima, Miwa× Teraoka, Hiroki× Unno, Toshihiro× Komori, Sei-ichi× Yamada, Masahisa× Kitazawa, Takio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although muscarinic M_2 and M_3 receptors are known to be important for regulation of gastric and small intestinal motility, muscarinic receptor subtypes regulating colonic function remain to be investigated. The aim of this study was to characterize muscarinic receptors involved in regulation of colonic contractility. M_2 and/or M_3 receptor knockout (KO) and wild-type mice were used in in vivo (defecation, colonic propulsion) and in vitro (contraction) experiments. Amount of feces was significantly decreased in M_3R-KO and M_2/M_3R-KO mice but not in M_2R-KO mice. Ranking of colonic propulsion was wild-type = M_2R-KO > M_3R-KO > M_2/M_3R-KO. In vitro, the amplitude of migrating motor complexes in M_2R-KO, M_3R-KO and M_2/M_3R-KO mice was significantly lower than that in wild-type mice. Carbachol caused concentration-dependent contraction of the proximal colon and distal colon from wild-type mice. In M_2R-KO mice, the concentration-contraction curves shifted to the right and downward. In contrast, carbachol caused non-sustained contraction and relaxation in M_3R-KO mice depending on its concentration. Carbachol did not cause contraction but instead caused relaxation of colonic strips from M_2/M_3R-KO mice. 4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride (McN-A-343) caused a non-sustained contraction of colonic strips from wild-type mice, and this contraction was changed to a sustained contraction by tetrodotoxin, pirenzepine and L-nitroarginine methylester (L-NAME). In the colon of M_2/M_3R-KO mice, McN-A-343 caused only relaxation, which was decreased by tetrodotoxin, pirenzepine and L-NAME. In conclusion, M_1, M_2 and M_3 receptors regulate colonic motility of the mouse. M_2 and M_3 receptors mediate cholinergic contraction, but M_1 receptors on inhibitory nitrergic nerves counteract muscarinic contraction. | |||||
書誌情報 |
European Journal of Pharmacology 巻 670, 号 1, p. 236-243, 発行日 2011-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-2999 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2011.08.034 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |