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Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats
http://hdl.handle.net/10659/00005407
http://hdl.handle.net/10659/00005407e0d67e71-c8bf-4875-bff1-f2cead6e44eb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2017-107_Iwano.pdf (887.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-12 | |||||
| タイトル | ||||||
| タイトル | Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bisphenol A | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diconjugation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glucuronide conjugation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | liver perfusion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sulfate conjugation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
INOUE, Hiroki
× INOUE, Hiroki× KEMANAI, Shino× SANO, Chie× KATO, Seiyu× YOKOTA, Hiroshi× 岩野, 英知 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In isolated hepatocytes, the environmental estrogen bisphenol A (BPA) is metabolized into a mono-glucuronide and a glucuronide/sulfate diconjugate. Little is known about the fate of the diconjugate in the liver. The present study focused on the metabolism and dispostion of BPA diconjugate in the liver using a perfusion method. In Sprague-Dawley rats, BPA (15,150 or 1,500 nmol) was applied into the liver. In male rats, the infused BPA was conjugated to both glucuronide and a diconjugate during passage through the liver. The diconjugate was observed at high-dose application of the substrate. In female rats, the chemical was conjugated almost exclusively to the glucuronide in all doses utilized in this study. In both the male and female rats, the resultant metabolites were preferentially excreted into the bile. These results suggest that BPA is conjugated primarily to mono-glucuronide in rat liver; and that in males, diconjugate production occurs under conditions of high-dose exposure to BPA. | |||||
| 書誌情報 |
The Journal of veterinary medical science 巻 78, 号 5, p. 733-737, 発行日 2016-05 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1292/jvms.15-0573 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
