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Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs
http://hdl.handle.net/10659/00006310
http://hdl.handle.net/10659/0000631008891886-78ee-4bdb-a73e-1898b1e6ca0f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2019-49_oyama.pdf (790.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-26 | |||||
| タイトル | ||||||
| タイトル | Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dog | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pharmacokinetics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | robenacoxib | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sevoflurane | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | dog | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | pharmacokinetics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | robenacoxib | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | sevoflurane | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
OYAMA, Norihiko
× OYAMA, Norihiko× SANO, Tadashi× YAMAMORI, Mizuki× TAMURA, Jun× UMAR, Mohammed Ahmed× ENDO, Yusuke× ISHIKAWA, Yusyun× ITOH, Akifumi× 三好, 健二郎× 山下, 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Robenacoxib is a novel nonsteroidal anti-inflammatory drug approved for dogs. The present study aimed to evaluate influences of sevoflurane anesthesia on the distribution of robenacoxib in dogs. Ten healthy beagle dogs (1 to 11 years old, 9.3 to 14.3 kg body weight, 6 males and 4 females) were subcutaneously administered robenacoxib (2 mg/kg) under conscious condition or sevoflurane anesthesia inhaled a 1.3-fold predetermined individual minimum alveolar concentration of sevoflurane at a 28-day interval. The dogs under sevoflurane anesthesia were also mechanically ventilated and received fluid-therapy. On each occasion, serum samples were collected from the dogs before and at 5, 15, 30, 60, 120, 180, and 240 min after the robenacoxib administration. Serum robenacoxib concentration was measured by a liquid chromatography-tandem mass spectrometry. Maximum serum concentration of robenacoxib (C_<max>) was 2.2 µg/ml [range: 1.2-4.6] (median [range: minimum-maximum]) and time of C_<max> (T_<max>) was 90 min [range: 60-120] in the conscious dogs. In the sevoflurane-anesthetized dogs, the C_<max> significantly declined (1.3 µg/ml [range: 0.8-1.4], P=0.008) and T_<max> was delayed (120 min [range: 120-240], P=0.018) compared with those in the conscious dogs. The serum robenacoxib concentration at 240 min (C_<240>) decreased to 0.5 µg/ml [range: 0.2-0.9] in the conscious dogs, while it remained higher in the sevoflurane-anesthetized dogs (1.0 µg/ml [range: 0.3-1.4], P=0.011). In conclusion, the anesthetic procedure with sevoflurane, mechanically ventilated, and received fluid-therapy might affect the pharmacokinetics of subcutaneously administered robenacoxib in dogs. | |||||
| 書誌情報 |
Journal of Veterinary Medical Science 巻 80, 号 9, p. 1450-1455, 発行日 2018-09 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1292/jvms.17-0356 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Japanese Society of Veterinary Science | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
