WEKO3
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Five mAChR subtypes (M1-M5) are identified in mammals. Although conventional pharmacological analysis suggested the involvement of M3 subtype in the ACh-induced contraction of GI smooth muscles, mAChRs population in GI tract has been demonstrated to consist of M2 and M3 subtypes (7:3). Roles of dominant M2 receptor for GI function (motility) have not been well determined because of lack of subtype selective agonists and antagonists, and similarity of intercellular signaling of odd number of mAChRs (M1, M3 and M5) or even number of mAChRs (M2 and M4). In this article, we review recent studies on muscarinic function in GI smooth muscle contraction using mAChR subtype deficient mice (knockout (KO) mice). Since M2 and M3 receptors are dominantly expressed in the GI tract, M2KO, M3KO and M2/M3 double KO mice markedly contributed to understand the function of mAChRs. 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消化管に発現するムスカリン受容体種とその機能 : ムスカリン受容体ノックアウトマウスを用いての検討
http://hdl.handle.net/10659/0002000107
http://hdl.handle.net/10659/0002000107a5689de2-c6c6-4adf-a610-ca2a56f92701
名前 / ファイル | ライセンス | アクション |
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S-48-2-255-276.pdf
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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公開日 | 2024-03-12 | |||||||||||
タイトル | ||||||||||||
言語 | ja | |||||||||||
タイトル | 消化管に発現するムスカリン受容体種とその機能 : ムスカリン受容体ノックアウトマウスを用いての検討 | |||||||||||
タイトル | ||||||||||||
言語 | ja-Kana | |||||||||||
タイトル | ショウカカン ニ ハツゲン スル ムスカリン ジュヨウタイシュ ト ソノ キノウ : ムスカリン ジュヨウタイ ノックアウト マウス オ モチイテ ノ ケントウ | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Physiological roles of muscarinic acetylcholine receptor in the gastrointestinal tract : Functional study using muscarinic receptor knockout mice | |||||||||||
言語 | ||||||||||||
言語 | jpn | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
北澤,多喜雄
× 北澤,多喜雄
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Acetylcholine (ACh) released from parasympathetic postganglionic nerves regulates the function of visceral organs such as gastrointestinal (GI) tract through activation of muscarinic acetylcholine receptors (mAChRs). Five mAChR subtypes (M1-M5) are identified in mammals. Although conventional pharmacological analysis suggested the involvement of M3 subtype in the ACh-induced contraction of GI smooth muscles, mAChRs population in GI tract has been demonstrated to consist of M2 and M3 subtypes (7:3). Roles of dominant M2 receptor for GI function (motility) have not been well determined because of lack of subtype selective agonists and antagonists, and similarity of intercellular signaling of odd number of mAChRs (M1, M3 and M5) or even number of mAChRs (M2 and M4). In this article, we review recent studies on muscarinic function in GI smooth muscle contraction using mAChR subtype deficient mice (knockout (KO) mice). Since M2 and M3 receptors are dominantly expressed in the GI tract, M2KO, M3KO and M2/M3 double KO mice markedly contributed to understand the function of mAChRs. Using these KO mice, in addition to activation of individual M2R/Gi/o and M3R/Gq/11 pathways, M2R/Gi/o M3RGq/11 (M2 R/M3 R heterodimer) pathway might be also stimulated by ACh and three pathways produce a complex cascade of biochemical and electrical events in smooth muscle cell, finally leading to GI smooth muscle contraction. Cellular signaling events induced by mAChRs include adenylyl cyclase inhibition (M2), phosphoinositide hydrolysis (M3), intracellular Ca2+ mobilization (M3), Ca2+ sensitization (M3), activation of non-selective cationic channel (M2, M3 and M2/M3), and modulation of Cl- or K+ channel (M3), inhibition/potentiation of voltage-dependent Ca2+ channel (M2, M3 and M2/M3) and membrane depolarization (M2, M3 and M2/M3). mAChRs are also expressed in the enteric cholinergic neurons, intestinal mucosal cells, and interstitial cells of Cajal, and negative feedback of ACh release, homeostasis of mucosal function and regulation of peristalsis by ACh/mAChRs have been suggested. In addition, use of mAChRs KO mice unmasks M1-mediated nitrergic pathway causing GI relaxation. Therefore, various types of mAChR KO mice show valuable insights for physiological roles of ACh/mAChR signaling system in GI tract and other organs. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
ja : 酪農学園大学紀要. 自然科学編 巻 48, 号 2, p. 255-276, 発行日 2024-03 |
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ISSN | ||||||||||||
収録物識別子タイプ | EISSN | |||||||||||
収録物識別子 | 2187-0500 | |||||||||||
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識別子タイプ | NCID | |||||||||||
関連識別子 | AN00247860 | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
言語 | ja | |||||||||||
出版者 | 酪農学園大学 | |||||||||||
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内容記述タイプ | Other | |||||||||||
内容記述 | Bulletin | |||||||||||
言語 | ja |