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Cancer Chemopreventive Ability of Conjugated Linolenic Acids
http://hdl.handle.net/10659/2999
http://hdl.handle.net/10659/29998bb73b60-fb4b-4e79-ba1e-0fb8075120b9
名前 / ファイル | ライセンス | アクション |
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S-2012-159_yasui.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Cancer Chemopreventive Ability of Conjugated Linolenic Acids | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CLN | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CLA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plant seed oils | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer chemoprevention | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPARγ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tanaka, Takuji
× Tanaka, Takuji× Hosokawa, Masashi× Yasui, Yumiko× Ishigamori, Rikako× Miyashita, Kazuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conjugated fatty acids (CFA) have received increased interest because of their beneficial effects on human health, including preventing cancer development. Conjugated linoleic acids (CLA) are such CFA, and have been reviewed extensively for their multiple biological activities. In contrast to other types of CFAs including CLA that are found at low concentrations (less than 1%) in natural products, conjugated linolenic acids (CLN) are the only CFAs that occur in higher quantities in natural products. Some plant seeds contain a considerably high concentration of CLN (30 to 70 wt% lipid). Our research group has screened CLN from different plant seed oils to determine their cancer chemopreventive ability. This review describes the physiological functions of CLN isomers that occur in certain plant seeds. CLN are able to induce apoptosis through decrease of Bcl-2 protein in certain human cancer cell lines, increase expression of peroxisome proliferator-activated receptor (PPAR)-γ, and up-regulate gene expression of p53. Findings in our preclinical animal studies have indicated that feeding with CLN resulted in inhibition of colorectal tumorigenesis through modulation of apoptosis and expression of PPARγ and p53. In this review, we summarize chemopreventive efficacy of CLN against cancer development, especially colorectal cancer. | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 12, 号 11, p. 7495-7509, 発行日 2011-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1422-0067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms12117495 | |||||
権利 | ||||||
権利情報 | © 2011 by the authors; licensee MDPI, Basel, Switzerland. | |||||
権利 | ||||||
権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/). | |||||
権利 | ||||||
権利情報 | http://creativecommons.org/licenses/by/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | MDPI | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |