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Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis
http://hdl.handle.net/10659/2974
http://hdl.handle.net/10659/29749449f810-7fa0-43b2-bcce-cc678b87314b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2012-193_Miyasho.pdf (5.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-06-04 | |||||
| タイトル | ||||||
| タイトル | Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ebina, Masahito
× Ebina, Masahito× Taniguchi, Hiroyuki× Miyasho, Taku× Yamada, Shingo× Shibata, Naoko× Ohta, Hiromitsu× Hisata, Shu× Ohkouchi, Shinya× Tamada, Tsutomu× Nishimura, Hidekazu× Ishizaka, Akitoshi× Maruyama, Ikuro× Okada, Yoshinori× Takashi, Kondo× Nukiwa, Toshihiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF. | |||||
| 書誌情報 |
Pulmonary Medicine 巻 2011, p. 916486-1-916486-9, 発行日 2011-02 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1155/2011/916486 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2011 Masahito Ebina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| 権利 | ||||||
| 権利情報 | http://creativecommons.org/licenses/by/2.0 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Hindawi Publishing Corporation | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
