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  1. 1:大学
  2. 2.獣医学群
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  4. 学術論文(雑誌)

High Mobility Group Box 1 (HMGB1) Protein is Present in the Cerebrospinal Fluid of Dogs with Encephalitis

http://hdl.handle.net/10659/3183
http://hdl.handle.net/10659/3183
1b72eb8e-8bc2-4ea8-84fa-5d0d8c949eb7
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-04
タイトル
タイトル High Mobility Group Box 1 (HMGB1) Protein is Present in the Cerebrospinal Fluid of Dogs with Encephalitis
言語
言語 eng
キーワード
主題Scheme Other
主題 biomarker
キーワード
主題Scheme Other
主題 canine
キーワード
主題Scheme Other
主題 CSF
キーワード
主題Scheme Other
主題 encephalitis
キーワード
主題Scheme Other
主題 HMGB1
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 宮庄, 拓

× 宮庄, 拓

WEKO 6518
教員総覧 9412

en MIYASHO, Taku

ja 宮庄, 拓


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NAKAMURA, Kozo

× NAKAMURA, Kozo

WEKO 9488

NAKAMURA, Kozo

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NOMURA, Sachiko

× NOMURA, Sachiko

WEKO 9489

NOMURA, Sachiko

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KAWASAKO, Kazufumi

× KAWASAKO, Kazufumi

WEKO 9490

KAWASAKO, Kazufumi

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NAKADE, Tetsuya

× NAKADE, Tetsuya

WEKO 4513
教員総覧 da802e47c9b2cc7e930bba8eb81e1bd9

NAKADE, Tetsuya

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YAMADA, Shingo

× YAMADA, Shingo

WEKO 9491

YAMADA, Shingo

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YOKOTA, Hiroshi

× YOKOTA, Hiroshi

WEKO 5064
教員総覧 8184870828dad297fd33fb02742dac14

YOKOTA, Hiroshi

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内容記述タイプ Abstract
内容記述 Many cases of encephalitic disease with unknown etiologies have been reported in specific breeds of small dogs. High mobility group box 1 (HMGB1) in neuronal cells was recently found to be a novel cytokine-like mediator that is a marker of neuronal necrosis and inflammation. The aim of this study was to determine whether HMGB1 levels are elevated in the cerebrospinal fluid (CSF) of dogs suspected of having encephalitis. CSF was obtained from 31 dogs that were diagnosed with an encephalitic disease by clinical examinations and magnetic resonance image (MRI) scanning. The CSF samples were analyzed via western blotting (WB) and an enzyme-linked immunosorbent assay (ELISA) with a polyclonal antibody against HMGB1. The mean HMGB1 concentration was significantly higher in the encephalitic dogs than that in the healthy controls. The concentrations of HMGB1 were correlated with the cell counts and total protein concentrations, which are known CSF indicators of the neuronal inflammation associated with encephalitis. These results suggest that HMGB1 protein in CSF confirms the presence of necrosis and inflammation in most cases of canine encephalitis and that HMGB1 will be a new indicator of encephalitis.
書誌情報 The journal of veterinary medical science

巻 73, 号 7, p. 917-922, 発行日 2011-07
DOI
識別子タイプ DOI
関連識別子 10.1292/jvms.10-0444
出版者
出版者 日本獣医学会
資源タイプ
内容記述タイプ Other
内容記述 Article
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